BOSTON — Scientists said Thursday that they have isolated a gene that instructs the body to build tiny new blood vessels, a crucial step in cancer growth, and they say this could open new strategies to defeat malignancies.
The researchers who purified and analyzed the protein, named angiogenin, which this gene controls, say it is the first time that an organ-forming protein has been understood in detail.
The discovery is the culmination of 10 years of work by Dr. Bert L. Vallee and colleagues at Harvard Medical School. Three scientific papers describing their research are being published in the latest issue of the journal Biochemistry.
Experts say the work represents a major step in the study of angiogenesis, or blood vessel formation, which was pioneered two decades ago by Dr. Judah Folkman, another Harvard researcher.