Researchers at Childrens Hospital of Los Angeles and the USC School of Medicine say they can now identify many people who have inherited a defective gene known to be responsible for retinoblastoma, a childhood cancer of the eye.
The report in the current issue of Science is the latest from scientists who have isolated the gene. The Childrens Hospital team said its study provided the first proof that the gene that was isolated is indeed the gene responsible for the cancer.
Dr. Yuen-Kai Fung said isolating the gene has enabled the researchers to identify certain children who inherited the damaged gene. And Dr. William F. Benedict said a test to establish whether a fetus is carrying the damaged gene may now be possible.
Over the years researchers have learned that retinoblastoma occurs in both a hereditary and a non-hereditary form. If both eyes are affected, the disease is hereditary; if only one eye is involved, it is non-hereditary in 85% of the cases, according to Benedict.