Unfortunately, cholesterol isn't the only substance washed out of the body by SPE. Because it acts as a fat does, SPE mixes with fat-soluble vitamins, such as A and E, in the intestines. And since the SPE isn't absorbed, these vitamins are not absorbed well either, the American Journal on Clinical Nutrition says.
Unfortunately, P&G's tests of olestra don't furnish convincing evidence of safety. For instance, in a test during which rats were fed SPE for two years, 48% of the males that were fed the highest dose died before the end of the experiment.