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SCIENCE FILE | Science in Brief

Canadian Researchers Breed Mouse With Alzheimer's Disease Symptoms

May 29, 1997|From Times staff and wire reports

Canadian researchers have created a mutant mouse that displays many of the symptoms of Alzheimer's disease, according to a report in the journal Nature. The genetically engineered mice mimic the disease better than previously developed models and should provide new insights into the disease mechanism, as well as a tool for testing new treatments.

Jo Nalbantoglu of McGill University in Montreal and colleagues said their mice lost cells in the hippocampus, the part of the brain associated with learning and memory, showed degeneration of brain cells and had the beta-amyloids that form the characteristic "plaques" in the brains of Alzheimer's patients.

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