The Houston Comets came to New York and handed the Liberty with its worst loss.
"We have our heads in our hands," Liberty forward Sue Wicks said after the Comets breezed to a 79-54 victory before 17,404 on Wednesday night.
Cynthia Cooper scored 17 of her 23 points in the first half as the Comets (11-1) handed the Liberty (8-6) its first loss at home.
The 25-point defeat topped a 19-point loss to Phoenix last year.
Houston made 10 of 18 three-point shots, including six by Cooper, the WNBA's leading scorer.
Phoenix 78, Detroit 76--Jennifer Gillom had 24 points, including a three-point basket as time expired, to give the Mercury (8-3) a victory over the Shock (6-6) before 9,276 at Auburn Hills, Mich.