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Vaccine Effective in Mice Could Help Alzheimer's

April 08, 2002|From Times Wire Reports

A single dose of an antibody that cleans up brain-clogging proteins improves memory in mice and might lead to an Alzheimer's disease vaccine for people, researchers reported.

A team at Lilly Research Laboratories in Indianapolis, owned by Eli Lilly; Washington University in St. Louis; and Universite Louis Pasteur in Strasbourg, France, has been reporting steady progress in mice with an antibody called m266.

In the mice, genetically engineered to develop a syndrome similar to Alzheimer's, the antibody homes in on the beta amyloid peptide, which forms the brain-clogging "plaques" seen in the disease.

Results of the study were reported in Nature Neuroscience.

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