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Pfizer's disappointment may lead to progress

The industry could gain insight from the failure of a new approach to fighting heart disease.

December 05, 2006|Daniel Yi | Times Staff Writer

"They will be mining [Pfizer's] data to see what they can glean and adapt their clinical trials accordingly," he said. "Science is not about home runs. There are a lot of singles and doubles. This was a long out, but every time you go up against a pitcher, you learn something."

daniel.yi@latimes.com

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(BEGIN TEXT OF INFOBOX)

Top pharmaceuticals

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Cholesterol drugs are the world's biggest-selling prescription medications . . .

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Leading classes of drugs, ranked by global 2005 sales (In billions)

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Cholesterol and triglyceride reducers: $32.4

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Cytostatics (for treatment of tumors): $28.5

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Anti-ulcerants: $26.7

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Antidepressants and mood stabilizers: $19.8

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Antipsychotics: $16.2

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Angiotensin-II inhibitors (high blood pressure): $14.2

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Erythropoietin products (anemia): $12.3

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Calcium antagonists plain (strokes): $11.9

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Anti-epileptics: $11.6

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Oral anti-diabetics: $10.7

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. . . with Pfizer's cholesterol treatment Lipitor the

world's bestselling prescription drug

Leading drugs, ranked by global 2005 sales (In billions)

*--* Drug Primary maker Purpose Sales Lipitor Pfizer Cholesterol $12.9 Plavix Bristol-Myers Squibb, Blood thinner $5.9 Sanofi-Aventis Nexium AstraZeneca Heartburn/ulcers $5.7 Seretide/Advair GlaxoSmithKline Allergies $5.6 Zocor* Merck Cholesterol $5.3 Norvasc Pfizer High blood pressure $5.0 Zyprexa Eli Lilly Schizophrenia $4.7 Risperdal Janssen Schizophrenia $4.0 Ogastro/Prevacid TAP Pharmaceutical Heartburn/ulcers $4.0 Effexor Wyeth Depression $3.8

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*Zocor lost its patent this year and sales have dropped.

Sources: IMS Health, Times research

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