Other interest groups are pointing to Tuesday's results as vindication of their particular causes, and as proof that Democrats should embrace their issues rather than shun them as too liberal.
Planned Parenthood Federation of America, which advocates abortion rights, pointed to victories by like-minded candidates in conservative states and a rejection by South Dakota voters of an abortion ban. The result, the group says, should be that Democrats view their causes as mainstream, rather than part of a liberal agenda, and should devote more money to contraception and other family-planning options opposed by religious conservatives and scaled back by the administration.
"I honestly believe there was no bigger winner in this election than Planned Parenthood Action Fund and women's health," said Planned Parenthood President Cecile Richards, referring to the group's political arm.
At the Brady Campaign to Prevent Gun Violence, the leading gun-control advocacy group, President Paul Helmke has high hopes for the assault weapons ban -- and he can list races where candidates backed by his group defeated those supported by the National Rifle Assn.
But Helmke, a former Republican mayor of Fort Wayne, Ind., acknowledged that his challenge was to convince Democrats that his cause was not "radioactive." Many Democratic strategists have come to believe that supporting gun-control laws alienates rural voters and many independents.
"Guns are a tricky issue," Helmke said. "But the elections show there's nothing to be afraid of."
Still, the issues of abortion and guns underscore the tough decisions facing Reid and Pelosi as they try to please the party's core supporters while appealing to centrist voters.
The party's winning formula this year, after all, required candidacies from cultural conservatives such as Rep.-elect Heath Shuler in western North Carolina and Sens.-elect Jon Tester in Montana and Jim Webb in Virginia.
A preview of the tussle that awaits Reid and Pelosi has been playing out on the Internet since election day, with liberal bloggers decrying party centrists as out of touch with the Democratic majority. The complaints have been serious enough to draw Reid's attention, prompting him to host a conference call after the election with more than a dozen of the country's most prominent liberal bloggers.