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Antidepressants may boost risk of fractures

January 23, 2007|Denise Gellene | Times Staff Writer

Daily antidepressant use doubled the risk of bone fractures in older adults, researchers reported Monday, raising new safety concerns about the widely prescribed drugs.

The study published in Archives of Internal Medicine found that about 10% of daily antidepressant users older than 50 fractured a bone over a five-year period. Among people who did not use antidepressants, the fracture rate was 5%.

Researchers said patients on antidepressants should be aware of the risks but should not stop taking their drugs because of worries about bone fractures.

It is important for such patients to get adequate calcium and exercise to maintain healthy bones, said Dr. Michael Bliziotes of Oregon Health & Science University, who is conducting similar research. He said the study didn't rule out that the underlying biology of depression, and not the drugs, accounted for the increased fracture risk.

"What this study points to is a need for heightened surveillance of these people," Bliziotes said.

The study, led by researchers at McGill University in Montreal, focused on a class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs. U.S. sales of the drugs, which include Prozac and Zoloft, totaled $10.9 billion in 2004, according to the report.

The medications are prescribed for a range of mood disorders and behaviors, including anxiety, depression and eating disorders. Last month, a federal advisory committee warned of a risk of suicidal thinking in young adults taking the drugs.

The latest study was part of the Canadian Multicentre Osteoporosis Study, a 10-year, 5,000-patient trial funded by the Canadian government, several companies that market osteoporosis drugs, including Eli Lilly and Co., which makes Prozac.

SSRIs were used daily by 137 people, or 2% of trial participants. Dr. David Goltzman of McGill University and senior author of the study, said the prevalence of antidepressant use was the same in the general population.

The study found that patients on antidepressants were twice as likely to fall and had lower bone mineral density at the hip and spine. Goltzman said it was likely the falls were caused by low blood pressure and fainting spells, two known side effects of SSRIs. The study took into account the increased falls and lower bone density, but still found a doubling of the risk for bone breakage, Goltzman said.

He said SSRIs appear to not only reduce bone thickness but also bone strength. "If you have two structures of the same thickness, and one is concrete and the other is glass, the glass will shatter more readily," he said.

Most patients' fractures occurred in the forearm, followed by the ankle and foot, hip, rib, shin and back, the study said.

Goltzman said patients already at risk for fractures should undergo bone density tests before going on antidepressants.

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denise.gellene@latimes.com

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