Generic? No thanks

Sometimes it is -- but not always.

It had taken me several years to convince Roger to take Lipitor (atorvastatin), a cholesterol-lowering medication. Although he didn't have known heart disease, his family history (his father had died of it at 55) and high cholesterol made it seem likely to me that his coronary arteries were already clogging up with plaque. He had begun to exercise two to three times a week, and he insisted he was improving his diet, eating less meat and dairy, and more vegetables, fish and fruit.

Nevertheless, his cholesterol numbers continued to climb. When his bad cholesterol (LDL) reached 155, he finally agreed to take a medicine to lower it. Studies had shown Lipitor's effectiveness at stabilizing coronary plaque and reducing heart attacks and strokes in patients with heart disease, so I started him on that.

In the past, Roger had tended to be intolerant of medications. He had occasional bouts of bronchitis and sinusitis, for which I would prescribe antibiotics. But because he often developed diarrhea and fatigue, he would sometimes stop them before the course was completed. He also suffered from gastric reflux disease, but reported that stomach medicines made him nauseated. I held my breath when he started Lipitor, but to my amazement, the days went by and he didn't call to complain.

Any muscle aches? I asked him when he returned to my office for blood tests. No, he said. In fact Roger had no complaints at all, and his blood tests showed normal muscle and liver enzymes, not to mention a dramatic lowering of his cholesterol.

We were both quite happy until the day a year ago that his insurance company decided it would no longer cover Lipitor. It suggested simvastatin instead, a new generic version of the cholesterol drug Zocor, another popular statin. Simvastatin hadn't fared quite as dramatically as Lipitor in studies, but it was a reasonable alternative and was generally well tolerated.

Still, it made no sense to me to change from a drug that was likely more effective and was being tolerated to one that was unknown. I intended to call the insurance company to protest, but in the meantime, Roger agreed to try simvastatin.