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Obese men less prone to suicide, study finds

Higher insulin levels may boost serotonin, a key brain chemical that regulates mood.

March 13, 2007|Denise Gellene | Times Staff Writer

A new study has found that obese men have a much lower risk of suicide, a finding that scientists think may be related to their higher production of insulin and other hormones that affect mood.

The study, published today in the Archives of Internal Medicine, reported that obese men were 42% less likely to commit suicide than those at the lower end of the normal-weight range.

Lead author Kenneth J. Mukamal of Beth Israel Deaconess Medical Center in Boston said he wasn't recommending that people overeat to stave off depression, noting that obesity carried numerous health risks, including diabetes and heart disease.

But the results, if replicated in a larger study, point to a new avenue for research into the role of hormones on mood, he said.

"I see this as a springboard for developing new and better ways to prevent suicide because, frankly, we don't have great ones now," Mukamal said.

He cautioned that the study was not applicable to women, in part because of hormone differences related to gender.

In addition, he said, the stigma of obesity falls more heavily on women, causing anxiety and other adverse effects on mood.

"Men can be jolly and fat," he said.

The research was based on the Health Professionals Follow-Up Study, a survey of 45,000 men -- dentists, veterinarians, optometrists and others -- that began in 1986.

The study examined the relationship between suicide and body mass index, a ratio of weight to height. For example, a man who is 6 feet tall and weighs 154 pounds has a body mass index, or BMI, of 21.

Researchers looked at men with BMIs ranging from below 20, which is considered underweight, to those above 30, which is considered obese.

The risk of suicide declined as BMI increased, suggesting that being fat exerted a protective effect against severe depression, the researchers said.

The study found that men with a BMI below 21 had a 39% greater risk of suicide than men in the low-normal range of 21 to 22.9.

The analysis was adjusted to take into account chronic diseases such as cancer and diabetes, and the use of antidepressants.

The researchers surmised that higher amounts of insulin in obese men increased their levels of serotonin, a key brain chemical that regulates mood. Most antidepressants act on serotonin.

The theory fit with other evidence on the relationship of insulin to mood. For example, the mood of Type 2 diabetics improves after receiving insulin. By contrast, postpartum depression in mothers of newborns is related to a drop in insulin.

Mukamal said obese men also produced larger amounts of leptin and sex hormones, which might serve to alleviate depression.

Dr. Julio Licinio, chairman of the department of psychiatry and behavioral sciences at the University of Miami School of Medicine, who was not connected with the research, said the findings fit with clinical experience that severely depressed people tended to lose weight, whereas mildly depressed people gained weight.

The study opens the possibility that obesity may be a response to depression, he said. Carbohydrate consumption is believed to boost serotonin levels, leading to an improved mood, he said.

"It could be they are eating to self-medicate depression, and as they do so they gain weight," Licinio said.

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denise.gellene@latimes.com

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