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Electrical stimulation relieves depression

July 26, 2008|Denise Gellene | Times Staff Writer

People with otherwise untreatable depression improved in a small clinical trial after receiving continuous electrical stimulation of a part of the brain that scientists believe regulates sadness.

A report this week in the journal Biological Psychiatry said 12 of 20 patients with chronic major depression benefited from the electronic device. For seven of the 12, the disease went into remission. The benefits were sustained over the course of the one-year study, researchers said.

"These were patients at the end of the road. They had tried other treatments and nothing seemed to stick," said University of Toronto neurosurgeon Andres M. Lozano, who led the study.

Major depressive disorder affects about 14 million people in the U.S., and 10% to 20% of them do not respond to standard medical treatment, according the study.

The nine men and 11 women in the trial had not improved on multiple medications, psychotherapy and electroconvulsive therapy. Subjects had been taking an average of four medications when the trial began in 2003 and had suffered from major depression for an average of 6.9 years.

Deep brain stimulation is approved to treat essential tremors and Parkinson's disease. Electrodes, which are permanently implanted in the brain, are powered by batteries and can be turned on and off by an external controller.

Six patients were able to return to work after two to seven years of unemployment because of their illness, according to the study, which was partly funded with a grant from device manufacturer Advanced Neuromodulation Systems Inc.

A larger study of 150 to 200 patients is underway, Lozano said.


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