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Eating away at illness

Tailored food plans such as the ketogenic diet are helping ease seizures and more.

May 12, 2008|Janet Cromley | Times Staff Writer
  • BENEFICIAL: In a ketogenic diet, fatty foods such as heavy whipping cream are a necessity.
BENEFICIAL: In a ketogenic diet, fatty foods such as heavy whipping cream… (Ricardo DeAratanha / Los…)

LYDIA BECKET was only 1 year old when the seizures started -- wracking convulsions that came in waves, often several a day.

For the next two years, her parents tried one medication after another: Tegretol, phenobarbital and Topamax. The same drugs that bring relief to many children with epilepsy just made her sicker.

Then Lydia's medical team put her on a ketogenic -- or high-fat, low-carbohydrate -- diet. Within a week, she was seizure-free.

"I don't know where we would be if it wasn't for that diet," says her mother, Camilla Becket, who has chronicled the stories of several families coping with epilepsy in the film "Childhood Epilepsy: What You Need to Know."

The diet, which is more than 85 years old and has been extensively studied, made headlines earlier this month when British researchers presented the strongest evidence to date of its efficacy. In a randomized controlled study of 145 children ages 2 to 16 who had more than seven seizures a week and were unresponsive to medication, senior author Dr. J. Helen Cross of the Institute of Child Health and Great Ormond Street Hospital in London reported a 38% reduction in mean seizure frequency among the 54 children assigned to receive the ketogenic diet.

The control group experienced an increase in seizures, according to the report, which appeared in the online edition of Lancet Neurology.

The results come as researchers and physicians are seeking ways to leverage the ketogenic diet to treat various other neurologic disorders, including ALS, brain tumors, autism, Parkinson's disease, Alzheimer's disease, narcolepsy and migraines. Many of these conditions respond to anticonvulsant medications, says Dr. Eric Kossoff, medical director of the Ketogenic Diet Center at Johns Hopkins Hospital, and the ketogenic diet seems to act as an anticonvulsant.

Using diet to control disease is nothing new. "For many conditions, we have come to accept special diets as routine parts of medicine," says Dr. George Christison, professor of psychiatry at Loma Linda University in Loma Linda.

Examples include diets low in simple carbohydrates (starches, sugars) for people with diabetes; low-fat diets high in fruits, vegetables and nuts for people with cardiovascular disease, phenylalanine-free diets for the genetic disorder phenylketonuria, low-sodium diets for hypertension and low-fat diets for gallstones. Some parents of children with autism spectrum disorders are putting their children on diets that eliminate foods with gluten and/or casein in the hopes that the diet may help, although the jury is still out on whether this diet is effective.

Most of these diets have an obvious cause-and-effect relationship to the disease, such as the lactose-free diet for the treatment of lactose intolerance and the gluten-free diet for celiac disease. But diets without this clear connection to the causes of a diseases are gathering steam in mainstream medicine as well. They include:

* Anti-inflammation diets. "Inflammation appears to be a common thread of many chronic diseases of aging, like Alzheimer's, heart disease, diabetes and common forms of cancer," says Dr. David Heber, director of UCLA's Center for Human Nutrition.

An anti-inflammatory diet involves reducing total fat, which by its nature reduces the amount of omega-6 fats, which are believed to promote inflammation. One consumes either fish three times a week or about 3 grams of fish oil supplement a day. This boosts levels of omega-3s, which have anti-inflammatory properties. Adherents also eat lots of richly colored fruits and vegetables, which are also anti-inflammatory.

The role of inflammation in disease is the subject of a growing body of research, including a study of 28,263 women appearing in the March 2000 New England Journal of Medicine, in which Harvard researchers found a strong link between a blood chemical linked to inflammation and cardiovascular health.

* Alteration of diet may also be powerful in prevention and treatment of eye disorders, says Allen Taylor, director of the nutrition and vision research lab at the USDA Human Nutrition Research Center on Aging at Tufts.

Taylor's group is studying the efficacy of a low-glycemic diet -- a diet low in simple carbohydrates -- in the prevention and treatment of macular degeneration and cataracts. The group has found that controlling spikes in blood sugar can result in diminished risk for age-related macular degeneration and cataracts. This benefit is achieved with dietary measures as simple as replacing white bread and pasta with whole grain breads and pastas, and by limiting sweet foods or drinks.

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