WASHINGTON — Cordell Hull was a veteran lawmaker with a worldwide reputation when Franklin D. Roosevelt appointed him secretary of State in 1933, in part to win needed support from Hull's army of Democratic admirers.
But the dignified Tennessean was never close to FDR. As time passed, he was "muscled out by others in the administration," said Michael Hunt, a diplomatic historian at the University of North Carolina.
Barack Obama's election as president has drawn other comparisons with Roosevelt's, especially for the economic crisis he inherits. But the example of Hull, a marginal figure despite the fact that he served into the 1940s and later won the Nobel Peace Prize, may point to potential pitfalls for Hillary Rodham Clinton if she takes the top diplomatic post, as seems increasingly likely.
Clinton would come to the role with global star power, a first-name relationship with world leaders, and a long familiarity with foreign policy.
But her relationship with the president and the new administration -- so key to success in the job -- is coarsely mixed. And her future ambitions could affect her pursuit of the administration's goals.
"I can imagine lots of room for friction," Hunt said, adding that strains between presidents and their top diplomats have been "a leitmotif of U.S. history."
The presence of her husband, former President Clinton, raises a range of additional questions.
From all outward appearances, Sen. Clinton and Obama have made peace. Yet they were rivals in the most protracted presidential primary in history, and that battle is certain to tint her arrival in the administration and on the world scene.
Throughout a long career, Clinton has been known for her diligence and grasp of details. Like the president-elect, she is thorough and methodical.
She met world leaders on a ceremonial level as first lady, but also knows many from her last five years as a member of the Senate Armed Services Committee who dealt with Iraq and Afghanistan. International leaders are aware that she is one of the most influential politicians in the United States.
"She'll bring stature and seriousness to a job that needs a real heavyweight," said former Ambassador Nancy Soderberg, who held a series of top-ranking foreign policy positions in the Clinton administration.