An analysis of more than 50 strains of the H1N1 influenza virus at the center of the global outbreak has concluded that they are closely related and can be fought with a single vaccine.
"We see much less variation among these new H1N1 viruses than we do for typical seasonal influenza viruses," said Nancy Cox, senior author of a study released Friday by the journal Science. That will make the job of creating a pandemic flu vaccine "much, much easier," she said.
Cox, who heads the influenza division at the Centers for Disease Control and Prevention in Atlanta, and colleagues from the U.S., Mexico and England also found that exposure to the normal seasonal flu strains provides little protection against the novel H1N1 that was identified in April.
Those findings could boost the likelihood that the U.S. will move forward with an H1N1 vaccine that would be offered separately from the seasonal flu vaccine.
The CDC is testing two potential seed stock candidates for an H1N1 vaccine to see whether they provoke an effective immune response.
The candidates combine portions of the H1N1 strain with other flu viruses that are known to grow efficiently in eggs, a key step in the vaccine-making process, said Dr. Anne Schuchat, interim deputy director for the CDC's Science and Public Health Program.
The agency expects to deliver a suitable seed stock to vaccine manufacturers by the end of the month, Schuchat said Friday.
In a related development, the Department of Health and Human Services announced Friday that it had set aside approximately $1 billion for development of an H1N1 vaccine. Some of the money will fund clinical trials of a vaccine over the summer, and some will be used to ramp up production of key vaccine ingredients in case they are needed, said Health Secretary Kathleen Sebelius.
The CDC has identified 6,552 cases of confirmed and probable H1N1 flu in the U.S., including nine deaths. For each patient identified, public health officials estimate an additional 20 people have mild symptoms. "We're estimating more than 100,000 people probably have this virus now in the U.S.," Schuchat said.
Worldwide, there have been 11,168 cases in 42 countries, including 86 deaths, the World Health Organization reported Friday.
The report in Science traced the origin of all eight genes that make up the H1N1 virus and found that in each case, the closest known relative is from a swine flu. That suggests that the virus had been circulating among pigs for some time before recently jumping to humans.
