A small preliminary study has found that valproic acid--a drug already used to treat epileptic seizures, migraines and bipolar disorder--may halt or even reverse the loss of vision produced by retinitis pigmentosa, researchers said Thursday. A team from the University of Massachusetts Medical School in Worchester is now organizing a clinical trial to confirm its observations.
Retinitis pigmentosa, commonly known as RP, is a group of eye diseases marked by degeneration of the retina, the part of the eye that captures images, leading to loss of peripheral vision and night vision. At least 40 genes have been linked to the condition and the particular manifestation of the disease depends on which genes are involved. The only effective treatment involves high levels of vitamin A palmitate, which can slow the progression of the disorder but not halt it. About one in 4,000 people is affected by RP, with many going blind by the age of 40.