He criticized the U.S. government for not focusing more on treatment and prevention and said easing drug laws would result in "serious consequences for American and Mexican society."
"Drugs kill in production. Drugs kill in distribution, as is the case in the violence in Mexico, and drugs kill in consumption," Calderon said.
The Obama administration disputed Calderon's claims of a softening stance on drugs. Gil Kerlikowske, the administration's drug czar, said he and the president have repeatedly expressed their opposition to legalization.
"We could not be clearer about why we oppose this for a whole host of really good reasons," Kerlikowske said.
Even some who back sweeping reform of drug laws doubt that voter approval of the California measure would yield quick results in Mexico's brutal drug war. But it would probably throw fuel on the debate south of the border.