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A drug that could kill most viruses?

BOOSTER SHOTS: ODDITIES, MUSINGS AND NEWS FROM THE
HEALTH WORLD

August 15, 2011|By Rosie Mestel, Los Angeles Times / For the Booster Shots blog
  • MIT scientists are working on a drug that could fight most viruses, such as influenza, shown here.
MIT scientists are working on a drug that could fight most viruses, such… (Centers for Disease Control…)

Viruses are tricky for a host of reasons: There are many different types, so a drug that fights one may not fight another. They use our cells' own machinery to replicate, so often drugs that would fight them would be toxic to our bodies.

Plus they replicate in huge numbers, and often sloppily -- producing many new forms. If one of those rare new forms happens to be resistant to an anti-viral drug, it will have a selective advantage and multiply -- and pretty soon you have a drug-resistant strain on your hands.

It obviously would be really useful if scientists could come up with a potent antiviral therapy that could be used against a broad array of viruses. Researchers at MIT's Lincoln Laboratory think they're on the way to doing just that. (They published their results in the journal PLOS One.)

The strategy takes advantage of a molecule called double-stranded RNA, which is produced by many, many viruses when they infect mammalian cells. Uninfected, our cells usually don't make this double-stranded RNA, and to some extent our cells have evolved to recognize this structure and respond. Just not potently enough. The drug created by the MIT team can enter mammalian cells and is engineered to induce the cells to commit suicide if -- and only if -- they contain double-stranded RNA.

The approach is called DRACO for short: J. K. Rowling would like that! (It stands for Double-stranded RNA Activated Caspase Oligomerizer, which doesn't trip off the tongue quite as magically.)

The strategy worked well in experiments with 11 different cell types in dishes, against 15 different virus types including dengue and H1N1 influenza, the scientists reported. And mice infected with H1N1 flu were cured of their infections.

It'll be interesting to see where this goes (lots of things look good in mouse  and lab-dish experiments but don't pan out later). Just think what it would mean for the flu, for example: For years, researchers have been  trying to come up with a universal flu vaccine so they don't have to make their best guess every year, starting months in advance,  about what three flu strains they should mass-produce in chicken eggs to process for the annual flu shot. 

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