The comedy in the script helped keep the atmosphere on set light. Rogen's Kyle, who has some trouble coming to terms with his friend's mortality, uses Adam's diagnosis as an opportunity to pick up women and smoke medical marijuana. Gordon-Levitt said he specifically appreciated the scenes involving the friends' awkward hook-up attempts.
"There are not nearly enough movies that show how the mating ritual is really just... not sexy at all," Gordon-Levitt said. "I know when I was younger, before I had a lot of those experiences, I bought into some of the fantasies that Hollywood sells about romance and sex. This movie says don't believe the hype. You don't have to have cancer to have nights like that, nights that are totally lame."
After the "50/50" screening, the Los Angeles native hosted a late-night event in Toronto titled "hitRECord at the Movies with Joseph Gordon-Levitt" as part of his moonlighting gig as head of the online production company "hitRECord," which he founded with his late brother, a performance artist who went by the name Burning Dan.
There was no sign of exhaustion as the lanky actor commandeered the stage, riffing on the videos he created with his online partners and bringing audience members to the stage to participate in readings that would likely make it into later pieces.