Stroke victims who are treated with blood-clot dissolving medications often recover better than people who don't receive the drugs. The medications, called tissue plasminogen activators, must be given within 4.5 hours of the first symptoms of stroke. Many people arrive at the hospital too late for the therapy.
One such group are people who wake up with symptoms of stroke and have no idea when their symptoms began. Now, however, research is suggesting that "wake-up" stroke patients should be treated with tPA.
Doctors typically avoid giving tPA to "wake-up" stroke victims because of safety concerns. The medications can cause bleeding in the brain. But the new study compared 326 patients who received the medications within 4.5 hours of the first stroke symptoms to 68 wake-up stroke patients who were also treated with tPA. Three months after the treatment patients in both groups had similar results in terms of death rates, risk of brain bleeding and recovery from the stroke.
As many as 20% of strokes are "wake-up" strokes, the authors said. Thus, the use of tPA in this group of people could be significant.