USC's Sept. 8 against Syracuse at MetLife Stadium in East Rutherford, N.J., will kick off at 12:30 p.m. PDT and will be televised by ABC, USC announced Tuesday.
The Trojans open the season against Hawaii on Sept. 1 at Los Angeles Memorial Coliseum. The kickoff time for that game and others are to be determined.
USC, led by quarterback Matt Barkley, is regarded as a front-runner for the Pac-12 Conference championship.
The Trojans, who finished 10-2 in 2011, are out from under a two-year bowl ban and are expected to be ranked among the top five in preseason polls.
USC is scheduled to open training camp in early August.