USC and UCLA, playing for the Pac-12 South Division title, will kickoff at noon Saturday at the Rose Bowl in a game that will be televised by Fox.
The winner advances to the conference championship game Nov. 30.
USC, 7-3 overall and 5-3 in conference play, remained No. 21 in the Associated Press media poll after defeating Arizona State, 38-17.
UCLA (8-2, 5-2) remained No. 17 with a 44-36 victory at Washington State.
USC defeated UCLA, 50-0, last season but was not eligible to play in the conference championship because of NCAA sanctions.
UCLA lost to Oregon, 49-31, in the title game.