Prescription sleep medications can be balm for the insomniac, but for many who take medications marketed as Ambien, Restoril and Lunesta, they can come with a cost: fogginess that can last into the next day. An experimental medication may help induce sleep without the hangover of impaired attention, memory and learning that is common with so-called hypnotic sedatives now available to consumers.
The investigational drug works on receptors in a region of the brain that's key for allowing us to fall into slumber: the lateral hypothalamus, where molecules called orexins are released throughout the day to keep us alert and awake. The medication, dubbed DORA-22, suppresses the activity of orexins in the lateral hypothalamus, allowing the consumer to drop off to sleep. Existing hypnotic sedatives work on so-called GABA receptors, which are found throughout the brain. That makes them a relative blunderbuss in inducing sleep and often results in residual effects.
Those effects prompted the FDA recently to order changes to the recommended dosing of Ambien, particularly for women and the elderly, among whom lingering cognitive effects have proved to be common.
In a study released Wednesday in the journal Science Translational Medicine, a team from Merck, the pharmaceutical company developing the new medication, demonstrated its effectiveness in inducing sleep in rats and rhesus monkeys. They found that, compared with rats and rhesus monkeys administered the sleep medications zolpidem (the generic name for Ambien), eszopiclone (Lunesta), or the sleep-inducing anti-anxiety drug diazepam (better known by its commercial name, Valium), those taking the experimental sleep drug had improved sleep without impairment of their cognitive performance.