USC's visit to Notre Dame in 2011 marked the Fighting Irish's first night home game in 21 years.
Two years later, the Trojans once again will be under the lights at Notre Dame Stadium.
USC's Oct. 19 game at South Bend, Ind., will kick off at 7:30 p.m. EST and will be televised by NBC, the schools announced Wednesday.
USC defeated Notre Dame, 31-17, two years ago.
The Trojans are to open the season Aug. 29 at Hawaii.
Kick-off times and broadcast information for games other than Notre Dame have yet to be announced.