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Alzheimer S Disease

People with below-average head size have as much as 18 times the normal risk of developing dementia caused by Alzheimer's and other diseases, Washington state researchers have found. The findings suggest that such individuals do not have enough brain cells in reserve to offset the loss of cells caused by aging and neurological diseases, said epidemiologist Amy B. Graves of Battelle Pacific Northwest Laboratories in Seattle.
July 20, 2011 | By Thomas H. Maugh II, Los Angeles Times/For the Booster Shots blog
Some signs of Alzheimer's disease appear in cerebrospinal fluid 10 or 20 years before symptoms of the disease appear in families with an inherited form of the disease, a finding that may help provide early diagnosis in those with sporadic forms of the disease, researchers said Wednesday. The findings may also provide a group of subjects in whom potential Alzheimer's drugs can be tested to determine if they work better when used at the earliest stages of the disease, according to researchers from the Washington University School of Medicine in St. Louis.
July 13, 2010 | By Karen Kaplan, Los Angeles Times
For patients with Alzheimer's disease, it helps to have a big head. That's the conclusion of a new study that examined the head circumferences of 270 participants in the Multi-Institutional Research in Alzheimer's Genetic Epidemiology study (or MIRAGE for short). Apparently, the extra cranial capacity affords patients some cognitive reserve, resulting in better brain function at any given level of cerebral atrophy. Researchers had previously noted an inverse relationship between cognitive performance and head circumference.
November 16, 2006 | Rong-Gong Lin II, Times Staff Writer
Alzheimer's disease for the first time has emerged as one of the leading causes of death in Los Angeles County, mirroring a fast-growing and increasingly costly nationwide trend tied to the aging baby boomer generation, health officials said Wednesday. The death rate from Alzheimer's jumped 220% -- or from 5 to 16 deaths out of every 100,000 people -- from 1994 to 2003, according to a new county Department of Public Health mortality report.
November 25, 1999
Molecular biologists have created a strain of mice that models one of the key features of Alzheimer's disease, the accumulation of "tangles" containing a protein called tau. The tangles, along with another deposit called plaque, are one of the key features of the disease, which affects as many as 4 million Americans. A team from the University of Pennsylvania reports in the November issue of Neuron that it added an extra copy of the tau gene to mice.
December 10, 2005 | From Times Staff and Wire Reports
The diabetes drug Avandia can enhance memory in patients with mild Alzheimer's disease, but only in patients with a certain genetic profile, researchers from GlaxoSmithKline reported Wednesday at a UC San Diego meeting. The finding supports the hypothesis that impaired glucose metabolism may play a role in the onset of the disorder. The study, using about 500 patients, showed that the drug worked only in patients who did not have a gene variant known as ApoE4.
January 31, 2005 | From Reuters
People who have high blood pressure, cholesterol, diabetes or who smoke in midlife have a much higher risk of developing Alzheimer's disease later on, U.S. researchers have found. And the more factors a person has, the higher the risk. People with all four risk factors have more than double the risk of Alzheimer's, reported a team at Kaiser Permanente's division of research in Oakland. "The message is that the risk factors that are bad for the heart are bad for the brain," said Dr.
September 5, 2002 | From Times Wire Reports
A government-sponsored trial aimed at seeing if painkillers can reduce the risk of Alzheimer's disease is not only useless, but dangerous and should be stopped, Public Citizen said. The consumer group, which has lobbied against certain diet pills and other drugs, said the study is using the wrong drugs.
Seated in her recliner in the family room of the Long Beach duplex she shares with her identical twin, 87-year-old Ilene Eddy is reminiscing about their childhood back on the family farm in Iowa. At least she's trying to. Her twin, Irene Peterson, a few feet away in her own recliner with its matching floral chair cover, keeps interrupting. "Irene, be quiet, please!" Ilene says. "I'm trying to give information here."
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