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Alzheimer S Disease

For much of her life, Sadie had it all: good health, a fine home, a family that adored her. But with old age came senility, robbing her, bit by bit, of her personality. Once known for her hearty appetite, she picked at her food, sometimes wandering off in the middle of a meal. She began getting lost in the only home she'd ever known. A lifelong extrovert, she sat for hours staring at the wall. Test after test came back normal. But the signs were all there: memory loss, confusion, inappropriate outbursts.
February 24, 1995 | TIM MAY
About 150,000 people in the Los Angeles area are afflicted with Alzheimer's disease, a dementia that can cause memory lapses and loss in mostly elderly patients, according to the national Alzheimer's Assn. "Every one of those persons is a potential wanderer," said Karen Jacobsen, director of the association's western region branch and chief of the local Safe Return program, aimed at tracking Alzheimer's patients who wander from their homes and speeding their safe return.
People with below-average head size have as much as 18 times the normal risk of developing dementia caused by Alzheimer's and other diseases, Washington state researchers have found. The findings suggest that such individuals do not have enough brain cells in reserve to offset the loss of cells caused by aging and neurological diseases, said epidemiologist Amy B. Graves of Battelle Pacific Northwest Laboratories in Seattle.
July 13, 2010 | By Karen Kaplan, Los Angeles Times
For patients with Alzheimer's disease, it helps to have a big head. That's the conclusion of a new study that examined the head circumferences of 270 participants in the Multi-Institutional Research in Alzheimer's Genetic Epidemiology study (or MIRAGE for short). Apparently, the extra cranial capacity affords patients some cognitive reserve, resulting in better brain function at any given level of cerebral atrophy. Researchers had previously noted an inverse relationship between cognitive performance and head circumference.
November 21, 2011
There's one thing that all Alzheimer's researchers agree on: The mind-robbing illness is heartbreaking. But after three decades of study that have produced neither cure nor medications that significantly slow its progress, some researchers are asking: What if it's not a disease with a cure? What if it's just an unfortunate but inevitable part of aging, along with wrinkly skin, osteoporosis and heart disease? In a study in the December issue of the Journal of Alzheimer's Disease, a research group led by Dr. Ming Chen at the University of South Florida suggests that "tremendous social pressures" have pushed scientists to target Alzheimer's as a curable disease.
November 25, 1999
Molecular biologists have created a strain of mice that models one of the key features of Alzheimer's disease, the accumulation of "tangles" containing a protein called tau. The tangles, along with another deposit called plaque, are one of the key features of the disease, which affects as many as 4 million Americans. A team from the University of Pennsylvania reports in the November issue of Neuron that it added an extra copy of the tau gene to mice.
December 10, 2005 | From Times Staff and Wire Reports
The diabetes drug Avandia can enhance memory in patients with mild Alzheimer's disease, but only in patients with a certain genetic profile, researchers from GlaxoSmithKline reported Wednesday at a UC San Diego meeting. The finding supports the hypothesis that impaired glucose metabolism may play a role in the onset of the disorder. The study, using about 500 patients, showed that the drug worked only in patients who did not have a gene variant known as ApoE4.
January 31, 2005 | From Reuters
People who have high blood pressure, cholesterol, diabetes or who smoke in midlife have a much higher risk of developing Alzheimer's disease later on, U.S. researchers have found. And the more factors a person has, the higher the risk. People with all four risk factors have more than double the risk of Alzheimer's, reported a team at Kaiser Permanente's division of research in Oakland. "The message is that the risk factors that are bad for the heart are bad for the brain," said Dr.
September 5, 2002 | From Times Wire Reports
A government-sponsored trial aimed at seeing if painkillers can reduce the risk of Alzheimer's disease is not only useless, but dangerous and should be stopped, Public Citizen said. The consumer group, which has lobbied against certain diet pills and other drugs, said the study is using the wrong drugs.
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