December 26, 2013 |
Elderly people who have both mild cognitive impairment and a history of serious concussion showed higher amounts of the protein deposits associated with Alzheimer's disease , according to a new study. The results, published Thursday in the journal Neurology, suggest a potential link between a history of head trauma and later cognitive decline. Researchers at the Mayo Clinic in Rochester, Minn., enlisted 589 elderly residents of surrounding Olmsted County, beginning in 2004, and administered a battery of cognitive and memory tests, along with brain scans that reveal both structure and metabolic function.
April 15, 1991 |
An important clue to the cause of memory loss associated with Alzheimer's disease has been discovered by researchers at City of Hope in Duarte. Biochemist Eugene Roberts and his City of Hope colleagues report today in the prestigious Proceedings of the National Academy of Sciences that injections of fragments of a brain protein called beta-amyloid into the brains of mice cause the animals to forget tasks they have just learned.
June 29, 2012 |
This post has been corrected. See note at the bottom for details. Who hasn't heard of mad cow disease? Maybe there are a lot more diseases like that than we recognize -- such as Parkinson's, Alzheimer's and Huntington's -- that are caused by a rogue, mis-folded piece of protein that seeds other bits of protein to mis-fold as well. So argues Stanley Prusiner, a UC San Francisco professor, in a commentary in the journal Science. Prusiner won a Nobel Prize for finding that a class of neurodegenerative diseases (of which mad cow is one)
CALIFORNIA | LOCAL
December 9, 1991 |
British scientists said last week that they had discovered a causal link between severe head injuries and Alzheimer's disease, a terminal brain disorder that afflicts an estimated 4 million elderly people in the United States. "It has been argued for a long time that Alzheimer's has several different causes. Our data is the first direct evidence that head injury may be one significant causative factor," said Dr. Gareth Roberts of London's St. Mary's Hospital Medical School.
January 22, 2007 |
Scientists have identified a gene that increases the risk for late-onset Alzheimer's and provides another clue into the complex mind-robbing disease. The gene -- SORL1 -- stands out because it's been tested in four ethnic groups and a form of it seems to confer a risk in all of them -- including North Europeans, Caribbean Latinos, African Americans and Israeli Arabs.
CALIFORNIA | LOCAL
July 8, 1999
Vaccination with a protein that plays a key role in Alzheimer's disease can halt progression of an Alzheimer's-like disorder in mice and may even reverse some of the symptoms, according to a report in today's Nature. The protein, called AN-1792, is a modified form of beta-amyloid peptide, one of the proteins found in the plaques and tangles in the brain characteristic of Alzheimer's disease.
December 3, 2010 |
Disease-modifying treatments for Alzheimer's disease have proved elusive. However, a study in mice published this week suggests that a treatment strategy relying on gene therapy may be worth pursuing. Researchers at the Gladstone Institute of Neurological Disease in San Francisco found that mice and humans with Alzheimer's disease have unusually low levels of an enzyme called EphB2 in the parts of the brain that control memory. EphB2 plays an important role in fostering communication between brain cells.
October 22, 1999 |
Scientists at Amgen have isolated an elusive brain chemical believed to play a crucial role in the development of Alzheimer's disease. Reporting their findings in today's edition of Science, the researchers hope the discovery will lead to targeted treatments that can halt the advance of this mind-devouring disease that afflicts an estimated 4 million Americans.
August 19, 2013 |
New research finds that copper in amounts readily found in our drinking water, the foods we eat and the vitamin supplements we take likely plays a key role in initiating and fueling the abnormal protein build-up and brain inflammation that are hallmarks of Alzheimer's disease. While the mineral is important to healthy nerve conduction, hormone secretion and the growth of bones and connective tissue, a team of researchers from the University of Rochester Medical Center suggested that too much of it may be a bad thing, and they set about to explore copper's dark side.
July 20, 2011 |
As Alzheimer's news goes, this tidbit is optimistic: An experimental drug to treat the memory-loss disease is safer than scientists originally expected. Researchers were concerned that bapineuzumab, a drug therapy being tested in mild to moderate Alzheimer's patients, carried the side effect of a brain swelling condition called vasogenic (cerebral) edema. But the brain swelling appears to go away, according to preliminary research presented this week. In one small clinical trial, researchers found there were fewer vasogenic edema cases as time went on. And the risk was smaller for lower doses of the drug.