April 8, 2002 |
A single dose of an antibody that cleans up brain-clogging proteins improves memory in mice and might lead to an Alzheimer's disease vaccine for people, researchers reported. A team at Lilly Research Laboratories in Indianapolis, owned by Eli Lilly; Washington University in St. Louis; and Universite Louis Pasteur in Strasbourg, France, has been reporting steady progress in mice with an antibody called m266.
CALIFORNIA | LOCAL
December 21, 2000 |
A potential Alzheimer's vaccine prevented a decline in learning and memory in mice, according to two new studies in today's Nature. The reports suggest a possibility that a vaccine can be developed to treat dementia and the loss of learning ability and memory associated with the disease in people. Tests involving humans could begin within a year.
December 3, 2010 |
Disease-modifying treatments for Alzheimer's disease have proved elusive. However, a study in mice published this week suggests that a treatment strategy relying on gene therapy may be worth pursuing. Researchers at the Gladstone Institute of Neurological Disease in San Francisco found that mice and humans with Alzheimer's disease have unusually low levels of an enzyme called EphB2 in the parts of the brain that control memory. EphB2 plays an important role in fostering communication between brain cells.
April 15, 1991 |
An important clue to the cause of memory loss associated with Alzheimer's disease has been discovered by researchers at City of Hope in Duarte. Biochemist Eugene Roberts and his City of Hope colleagues report today in the prestigious Proceedings of the National Academy of Sciences that injections of fragments of a brain protein called beta-amyloid into the brains of mice cause the animals to forget tasks they have just learned.
November 7, 2011 |
Two of the most worrisome trends in healthcare - the soaring rates of Type 2 diabetes and dementia - share several key biological processes. And scientists are beginning to think that is more than just a coincidence. Many researchers now believe that proper control of blood sugar could pay dividends in the future by reducing the number of people stricken by Alzheimer's disease, other forms of dementia and even the normal cognitive decline that comes with age. The concept that brain diseases share little in common with diseases arising elsewhere in the body is rapidly crumbling, says Debra Cherry, executive vice president of the Alzheimer's Assn.
CALIFORNIA | LOCAL
December 9, 1991 |
British scientists said last week that they had discovered a causal link between severe head injuries and Alzheimer's disease, a terminal brain disorder that afflicts an estimated 4 million elderly people in the United States. "It has been argued for a long time that Alzheimer's has several different causes. Our data is the first direct evidence that head injury may be one significant causative factor," said Dr. Gareth Roberts of London's St. Mary's Hospital Medical School.
January 22, 2007 |
Scientists have identified a gene that increases the risk for late-onset Alzheimer's and provides another clue into the complex mind-robbing disease. The gene -- SORL1 -- stands out because it's been tested in four ethnic groups and a form of it seems to confer a risk in all of them -- including North Europeans, Caribbean Latinos, African Americans and Israeli Arabs.
CALIFORNIA | LOCAL
July 8, 1999
Vaccination with a protein that plays a key role in Alzheimer's disease can halt progression of an Alzheimer's-like disorder in mice and may even reverse some of the symptoms, according to a report in today's Nature. The protein, called AN-1792, is a modified form of beta-amyloid peptide, one of the proteins found in the plaques and tangles in the brain characteristic of Alzheimer's disease.
October 22, 1999 |
Scientists at Amgen have isolated an elusive brain chemical believed to play a crucial role in the development of Alzheimer's disease. Reporting their findings in today's edition of Science, the researchers hope the discovery will lead to targeted treatments that can halt the advance of this mind-devouring disease that afflicts an estimated 4 million Americans.
June 29, 2012 |
This post has been corrected. See note at the bottom for details. Who hasn't heard of mad cow disease? Maybe there are a lot more diseases like that than we recognize -- such as Parkinson's, Alzheimer's and Huntington's -- that are caused by a rogue, mis-folded piece of protein that seeds other bits of protein to mis-fold as well. So argues Stanley Prusiner, a UC San Francisco professor, in a commentary in the journal Science. Prusiner won a Nobel Prize for finding that a class of neurodegenerative diseases (of which mad cow is one)