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Amyloid

CALIFORNIA | LOCAL
April 13, 2000
Researchers at the Oklahoma Medical Research Foundation say they have identified a highly effective inhibitor of the enzyme that plays a key role in the onset of Alzheimer's disease. Memapsin 2, also known as beta-secretase, cleaves a protein called amyloid precursor protein, producing protein fragments that damage brain cells. The team reported in Wednesday's Journal of the American Chemical Society that the new inhibitor blocks this process in the test tube. It has not been tested in humans.
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SCIENCE
August 19, 2013 | By Melissa Healy
New research finds that copper in amounts readily found in our drinking water, the foods we eat and the vitamin supplements we take likely plays a key role in initiating and fueling the abnormal protein build-up and brain inflammation that are hallmarks of Alzheimer's disease. While the mineral is important to healthy nerve conduction, hormone secretion and the growth of bones and connective tissue, a team of researchers from the University of Rochester Medical Center suggested that too much of it may be a bad thing, and they set about to explore copper's dark side.
NEWS
April 15, 1991 | THOMAS H. MAUGH II, TIMES SCIENCE WRITER
An important clue to the cause of memory loss associated with Alzheimer's disease has been discovered by researchers at City of Hope in Duarte. Biochemist Eugene Roberts and his City of Hope colleagues report today in the prestigious Proceedings of the National Academy of Sciences that injections of fragments of a brain protein called beta-amyloid into the brains of mice cause the animals to forget tasks they have just learned.
CALIFORNIA | LOCAL
December 9, 1991 | From Times Staff and Wire Reports
British scientists said last week that they had discovered a causal link between severe head injuries and Alzheimer's disease, a terminal brain disorder that afflicts an estimated 4 million elderly people in the United States. "It has been argued for a long time that Alzheimer's has several different causes. Our data is the first direct evidence that head injury may be one significant causative factor," said Dr. Gareth Roberts of London's St. Mary's Hospital Medical School.
HEALTH
January 22, 2007 | From Times wire reports
Scientists have identified a gene that increases the risk for late-onset Alzheimer's and provides another clue into the complex mind-robbing disease. The gene -- SORL1 -- stands out because it's been tested in four ethnic groups and a form of it seems to confer a risk in all of them -- including North Europeans, Caribbean Latinos, African Americans and Israeli Arabs.
CALIFORNIA | LOCAL
July 8, 1999
Vaccination with a protein that plays a key role in Alzheimer's disease can halt progression of an Alzheimer's-like disorder in mice and may even reverse some of the symptoms, according to a report in today's Nature. The protein, called AN-1792, is a modified form of beta-amyloid peptide, one of the proteins found in the plaques and tangles in the brain characteristic of Alzheimer's disease.
NEWS
December 3, 2010 | By Shari Roan, Los Angeles Times
Disease-modifying treatments for Alzheimer's disease have proved elusive. However, a study in mice published this week suggests that a treatment strategy relying on gene therapy may be worth pursuing. Researchers at the Gladstone Institute of Neurological Disease in San Francisco found that mice and humans with Alzheimer's disease have unusually low levels of an enzyme called EphB2 in the parts of the brain that control memory. EphB2 plays an important role in fostering communication between brain cells.
NEWS
October 22, 1999 | PAUL JACOBS, TIMES STAFF WRITER
Scientists at Amgen have isolated an elusive brain chemical believed to play a crucial role in the development of Alzheimer's disease. Reporting their findings in today's edition of Science, the researchers hope the discovery will lead to targeted treatments that can halt the advance of this mind-devouring disease that afflicts an estimated 4 million Americans.
NEWS
June 29, 2012 | By Rosie Mestel, Los Angeles Times / For the Booster Shots blog
This post has been corrected. See note at the bottom for details. Who hasn't heard of mad cow disease? Maybe there are a lot more diseases like that than we recognize -- such as Parkinson's, Alzheimer's and Huntington's  -- that are caused by a rogue, mis-folded piece of protein that seeds other bits of protein to mis-fold as well. So argues Stanley Prusiner, a UC San Francisco professor, in a commentary in the journal Science. Prusiner won a Nobel Prize for finding that a class of neurodegenerative diseases (of which mad cow is one)
SCIENCE
July 11, 2012 | By Thomas H. Maugh II, Los Angeles Times
Researchers have found the first gene mutation that protects against Alzheimer's disease, a finding that supports a now-controversial theory about the cause of the disease and that could eventually lead to the development of new drugs to treat the disorder. The gene mutation also protects against normal dementia of aging, suggesting that the two diseases have mechanisms in common. Alzheimer's affects an estimated 5.4 million Americans, and the prevalence increases with age: 13% of those older than 65 and 45% of those over the age of 85 have it. The disease is characterized by the buildup in the brain of particles called amyloid plaque, which are composed of a protein called amyloid beta.
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