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Antibodies

NEWS
May 20, 1988 | THOMAS H. MAUGH II, Times Science Writer
For the first time, researchers have been able to use genetic engineering techniques to produce key parts of disease-fighting antibodies in bacterial cells, a Santa Monica-based biotechnology company said in a report published today. Biologists at International Genetic Engineering Inc. (Ingene) used the technique to produce an antibody fragment that binds specifically to human colon cancer cells.
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BUSINESS
November 30, 1998 | PAUL JACOBS
In the December edition of Nature Biotechnology, researchers from Johns Hopkins University and ReProtect in Baltimore, Monsanto's Agracetus division in Wisconsin, and Protein Design Labs in Mountain View, Calif., report that they have been able to create soy plants that make antibodies to the genital herpes virus. There is still a long way to go before these antibodies are tested in humans and approved by regulators as safe and effective against herpes infection.
CALIFORNIA | LOCAL
November 27, 1985 | NANCY WRIDE, Times Staff Writer
The mother of an 11-year-old El Toro boy sought an injunction against the Saddleback Unified School District on Tuesday, claiming that he was expelled from school after it was discovered that he has an AIDS-linked antibody in his blood. School district officials said the boy had never been expelled but was being tutored at home at his mother's request.
CALIFORNIA | LOCAL
October 9, 1997
Injections of an antibody that targets a natural human protein are showing promise in hard-to-treat cases of Crohn's disease, a chronic digestive illness. The treatment involves injections of an antibody called cA2. It neutralizes a protein known as tumor necrosis factor that is believed to play a role in causing Crohn's disease. The study is published in today's New England Journal of Medicine. The treatment, which has not been approved for routine use, was developed by Centocor Inc.
CALIFORNIA | LOCAL
November 2, 1987
Dr. Leroy Hood, a Caltech molecular geneticist, in September was one of three scientists to win the prestigious Lasker Basic Medical Research Award for helping explain how the immune system creates an almost endless variety of antibodies to protect the human body from foreign invaders. The immune system is believed crucial to curing many of man's diseases, a fact reflected in the number of Nobel prizes granted in this field.
NEWS
September 6, 1991 | From Times Staff and Wire Reports
Up to 40% of operations to open clogged arteries fail when the vessels develop new blockages. Now a laboratory study with rats shows that an antibody may prevent this problem, offering new hope for human heart disease patients. Researchers at the University of Washington report that they have used an antibody extracted from goats to keep arteries clear in rats that underwent an operation commonly used in human heart disease to open up blocked vessels.
CALIFORNIA | LOCAL
October 30, 1995 | From Times staff and wire reports
Researchers studying the AIDS virus report in the journal Nature that it could remain infectious even when surrounded by neutralizing antibodies that would normally destroy it. A team at Virginia Commonwealth University examined follicular dendritic cells (FDCs) in the lymph nodes where large amounts of HIV, the AIDS virus, congregate.
CALIFORNIA | LOCAL
August 8, 1996 | From Times staff and wire reports
A highly toxic cancer drug linked to antibodies and directed against a protein on the surface of cancer cells can completely eradicate human colon tumors grown in mice without producing adverse side effects, researchers from ImmunoGen Inc. reported in the Aug. 6 Proceedings of the National Academy of Sciences. Colorectal cancer is one of the most common malignancies, striking about 140,000 Americans each year, killing 55,000. Surgery is the most common treatment.
NEWS
April 28, 1994 | THOMAS H. MAUGH II, TIMES MEDICAL WRITER
In a development that could lead to major improvements in the treatment of autoimmune diseases, cancer, AIDS and organ rejection in humans, two California companies report today that they have been able to genetically engineer mice so that they produce human antibodies. Mouse cells that produce these antibodies can then be grown in laboratory vats to produce large amounts of so-called monoclonal antibodies that, when given to patients, can attack and destroy diseased cells.
NATIONAL
August 13, 2002 | From Reuters
A growing herd of cloned calves may provide a variety of human antibodies to treat diseases ranging from childhood ear infections to smallpox, researchers said Monday. The cloned and genetically engineered calves carry not just a single human gene, but a section of genes that controls the production of many different antibodies, a team at privately owned Hematech reported.
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