June 8, 2011 |
Autism spectrum disorders can be caused by as many as 300 or so rare genetic mutations, scientists reported Wednesday. The research strongly implicates genetics, including spontaneous gene mutations, in the development of the disorder. But why do four times as many males as females develop autism spectrum disorder? In one of the three papers published in the journal Neuron , researchers suggest that girls are more resistant to gene mutations than boys. Girls seem to require a higher number of gene mutations to become afflicted with autism spectrum disorder.
June 9, 2011 |
Autism is not caused by one or two gene defects but probably by hundreds of different mutations, many of which arise spontaneously, according to research that examined the genetic underpinnings of the disorder in more than 1,000 families. The findings, reported in three studies published Wednesday in the journal Neuron, cast autism disorders as genetically very complex, involving many potential changes in DNA that may produce, essentially, different forms of autism. The affected genes, however, appear to be part of a large network involved in controlling the development of synapses, the critical junctions between nerve cells that allow them to communicate, according to one of the three studies.
April 24, 2013 |
Pregnant women who took the anti-seizure drug valproate during pregnancy increased the odds that their baby would have autism, and were roughly twice as likely to give birth to a child who would go on to be diagnosed with an autism spectrum disorder, according to a large study that captured 10 years of births in Denmark. Valproate, often known by its commercial name Depakote, is widely prescribed in the treatment of epilepsy and a wide range of psychiatric conditions. It is one of a class of drugs that has been linked to a child's delayed cognitive development and to some congenital malformations.
August 22, 2012 |
Men who become fathers later in life pass on more brand-new genetic mutations to their offspring, a study has found - probably contributing to disorders such as autism and schizophrenia in the next generation. The finding, published online Wednesday in the journal Nature , buttresses earlier observations that rates of autism and some other disorders are more prevalent in children born of older fathers, sometimes by a factor of two or more, experts said. Though this has been observed for years from population studies, scientists had not known what lay behind it. The new research, made possible by recent advances in DNA-sequencing technology, also should help correct an overemphasis on the riskiness of women giving birth at older ages, some researchers said.
October 11, 2010
UPDATED: An earlier version of this post incorrectly attributed the research to the University of Washington. Scientists at the Washington University School of Medicine have uncovered more evidence of a genetic basis for autism. Reviewing surveys collected from more than 1,000 families with autistic kids, they discovered that siblings of autistic children who have not been diagnosed with the disease often exhibit mild traits of autism, including speech delays. The team sifted through information about almost 3,000 children from 1,235 families in which at least one child was diagnosed with an autism spectrum disorder and in which there was at least one full biological sibling.
November 26, 2012 |
In a finding that points to a link between environmental toxins and autism, a new study shows that children who were exposed to the highest levels of traffic-related air pollution during gestation and in early infancy were three times more likely to be diagnosed with the neurodevelopmental disorder than were those whose early exposure to such pollutants was very low. The study , published Monday in the Archives of General Psychiatry, found that...