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ENTERTAINMENT
November 5, 2012 | By Christie D'Zurilla
Sharon Osbourne has had a preventive double mastectomy after learning she carried a mutated gene indicating a much higher risk of breast cancer, "The Talk" panelist has revealed to a British magazine. "For me, it wasn't a big decision, it was a no-brainer," she told Hello! "I didn't want to live the rest of my life with that shadow hanging over me. I want to be around for a long time and be a grandmother to Pearl. " Osbourne had previously battled colon cancer, and had her breast implants removed a year ago, declaring well in advance that once removed, the implants would be husband Ozzy Osbourne's to use as a paperweight.
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NEWS
August 8, 2011 | By Eryn Brown, Los Angeles Times / for the Booster Shots blog
Raymond Johnson, a 26-year-old construction worker fromCharleston, S.C., was recently denied Medicaid coverage for breast cancer treatment because he is a man. Johnson has said he was surprised to learn his diagnosis, which doctors discovered after he experienced chest pain over the July 4th weekend.  But every couple of years, a case of a man getting the disease puts men with breast cancer in the news.  In 2002, former Sen. Edward W. Brooke (R-Mass.)...
NEWS
May 14, 2013 | By Alexandra Le Tellier
Angelina Jolie's Op-Ed in the New York Times about getting a double mastectomy after learning that she was at risk of getting breast cancer struck a chord with fellow celebs as well as with Los Angeles Times staffers Anna Gorman and Paul Whitefield , who wrote about their own experiences Tuesday.  Jolie's Op-Ed specifically focuses on BRCA1 and BRCA2, known as the breast cancer genes. “I have always told [my kids] not to worry [about me getting cancer], but the truth is I carry a 'faulty' gene, BRCA1, which sharply increases my risk of developing breast cancer and ovarian cancer ,” she writes.
SCIENCE
April 15, 2013 | By Eryn Brown
As the U.S. Supreme Court heard oral arguments in the case against Myriad Genetics, scientists who are skeptical of the idea of patenting genes said they were hopeful that the justices would overturn the Utah company's claims. "I was on pins and needles the whole time," said Dr. Wayne Grody, director of the Diagnostic Molecular Pathology Laboratory at the Ronald Reagan UCLA Medical Center, who was present at the arguments. "But at the end I thought, 'The justices really get it' ... I felt that all of them who spoke weren't comfortable with the idea of patenting a gene.
CALIFORNIA | LOCAL
May 21, 2013 | By Robin Abcarian, Los Angeles Times
Four days after her April 27 breast reconstruction, the third and final surgery aimed at sparing her an early death from breast cancer, Angelina Jolie was in good spirits at home. Upon paying a house call, her surgeon, Dr. Kristi Funk of the Pink Lotus Breast Center in Beverly Hills, found two walls of the actress' home covered with "freshly assembled story boards" for her next directorial project. "All the while she spoke," the doctor later wrote on her blog, "six drains dangled from her chest, three on each side, fastened to an elastic belt around her waist.
NEWS
November 5, 2010 | By Thomas H. Maugh II, Los Angeles Times
The proportion of women having both breasts removed when breast cancer appears in one has increased more than ten-fold over a 10-year period, despite a limited amount of evidence showing a survival benefit for the procedure, researchers reported Wednesday. Nearly one in every 20 women now has the second breast removed in an effort to forestall the development of a tumor in it, Dr. Katherine Yao of the NorthShore University HealthSystem in Evanston, Ill. and her colleagues reported in the October issue of the Annals of Surgical Oncology.
NEWS
July 25, 2012 | By Rosie Mestel, Los Angeles Times
Maybe you've been reading a lot lately about the development of fetal DNA tests based on a curious fact -- that the blood of a pregnant woman contains tiny bits of DNA of the fetus. Several groups have recently used this fact to sequence the entire genome of a fetus and pick up the presence of extra chromosomes or even individual gene variants that would render the baby prone to health conditions. It's an important development with much promise, health researchers say, because it offers a way to detect genetic abnormalities very early, without the small but real risk of miscarriage that comes with today's widely used screening technologies: amniocentesis and chorionic villus sampling.
NEWS
May 14, 2013 | By Jon Healey
It's hard to imagine Supreme Court justices paying much attention to the travails of Hollywood's rich and famous. Still, there's an interesting connection between Angelina Jolie's disclosure Tuesday that she underwent a double mastectomy and a case the court is deliberating, the Assn. for Molecular Pathology vs. Myriad Genetics . At issue is whether a human gene sequence can be patented. That's the broad question. The two specific sequences patented by Myriad -- BRCA1 and BRCA2 -- are genes that suppress tumors . A small percentage of women have defective copies of those genes, and they are extremely likely to develop a virulent form of breast cancer.
SCIENCE
May 14, 2013 | By Anna Gorman
Late Monday night, friends and colleagues started sending me Angelina Jolie's op-ed about her decision to have a double mastectomy. Like Jolie, I have the mutation in my BRCA1 gene that pushed my lifetime risk of developing breast cancer to nearly 90%. (It also raised my risk of ovarian cancer above 50%.) Also like Jolie, I chose to get a double mastectomy to reduce my risk of breast cancer to less than 5%. In 2007, I wrote a first-person story in the Los Angeles Times about finding out I had this mutation and how I decided what to do about it. Jolie is an icon of beauty -- and her disclosure doesn't change that.
SCIENCE
August 31, 2010 | By Thomas H. Maugh II, Los Angeles Times
Preemptive removal of breasts or ovaries in women with two common breast cancer genes can sharply reduce the risk of contracting cancer and dying, even if a woman has already been diagnosed with breast cancer, a new study confirms. Researchers were already confident that such prophylactic surgeries reduce the risk of cancer, but the new study , reported Tuesday in the Journal of the American Medical Assn., is the largest such investigation to date and the first to differentiate the benefits based on which gene a woman has and whether or not she has already had cancer.
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