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ENTERTAINMENT
November 5, 2012 | By Christie D'Zurilla
Sharon Osbourne has had a preventive double mastectomy after learning she carried a mutated gene indicating a much higher risk of breast cancer, "The Talk" panelist has revealed to a British magazine. "For me, it wasn't a big decision, it was a no-brainer," she told Hello! "I didn't want to live the rest of my life with that shadow hanging over me. I want to be around for a long time and be a grandmother to Pearl. " Osbourne had previously battled colon cancer, and had her breast implants removed a year ago, declaring well in advance that once removed, the implants would be husband Ozzy Osbourne's to use as a paperweight.
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NEWS
May 14, 2013 | By Alexandra Le Tellier
Angelina Jolie's Op-Ed in the New York Times about getting a double mastectomy after learning that she was at risk of getting breast cancer struck a chord with fellow celebs as well as with Los Angeles Times staffers Anna Gorman and Paul Whitefield , who wrote about their own experiences Tuesday.  Jolie's Op-Ed specifically focuses on BRCA1 and BRCA2, known as the breast cancer genes. “I have always told [my kids] not to worry [about me getting cancer], but the truth is I carry a 'faulty' gene, BRCA1, which sharply increases my risk of developing breast cancer and ovarian cancer ,” she writes.
SCIENCE
April 15, 2013 | By Eryn Brown
As the U.S. Supreme Court heard oral arguments in the case against Myriad Genetics, scientists who are skeptical of the idea of patenting genes said they were hopeful that the justices would overturn the Utah company's claims. "I was on pins and needles the whole time," said Dr. Wayne Grody, director of the Diagnostic Molecular Pathology Laboratory at the Ronald Reagan UCLA Medical Center, who was present at the arguments. "But at the end I thought, 'The justices really get it' ... I felt that all of them who spoke weren't comfortable with the idea of patenting a gene.
NEWS
April 15, 2013 | By Peter D. Meldrum
In their April 12 Op-Ed article " Who should own DNA? All of us ," Marcy Darnovsky and Karuna Jaggar write about Myriad's patents on BRCA1 and BRCA2, the so-called breast cancer genes (which were under review Monday at the U.S. Supreme Court), as if they have served little purpose in the development of tests that have helped more than 1 million women to understand their risks of breast cancer and ovarian cancer. The patents do not cover human genes from anyone's body.
HEALTH
November 1, 2011 | By Shari Roan, Los Angeles Times
Drinking as few as three to six glasses of wine per week may increase a woman's lifetime risk of breast cancer by 15%, according to an analysis by Harvard researchers. The study, published Tuesday in the Journal of the American Medical Assn., reaffirms that heavy alcohol use raises breast cancer risk, and it adds that light drinking matters too. "Alcohol is a real risk factor, and the more you drink the higher your risk," said Dr. Steven A. Narod, the Canada research chair in breast cancer at the University of Toronto, who wrote a commentary accompanying the study.
SCIENCE
August 31, 2010 | By Thomas H. Maugh II, Los Angeles Times
Preemptive removal of breasts or ovaries in women with two common breast cancer genes can sharply reduce the risk of contracting cancer and dying, even if a woman has already been diagnosed with breast cancer, a new study confirms. Researchers were already confident that such prophylactic surgeries reduce the risk of cancer, but the new study , reported Tuesday in the Journal of the American Medical Assn., is the largest such investigation to date and the first to differentiate the benefits based on which gene a woman has and whether or not she has already had cancer.
NEWS
November 5, 2010 | By Thomas H. Maugh II, Los Angeles Times
The proportion of women having both breasts removed when breast cancer appears in one has increased more than ten-fold over a 10-year period, despite a limited amount of evidence showing a survival benefit for the procedure, researchers reported Wednesday. Nearly one in every 20 women now has the second breast removed in an effort to forestall the development of a tumor in it, Dr. Katherine Yao of the NorthShore University HealthSystem in Evanston, Ill. and her colleagues reported in the October issue of the Annals of Surgical Oncology.
SCIENCE
May 14, 2013 | By Anna Gorman
Late Monday night, friends and colleagues started sending me Angelina Jolie's op-ed about her decision to have a double mastectomy. Like Jolie, I have the mutation in my BRCA1 gene that pushed my lifetime risk of developing breast cancer to nearly 90%. (It also raised my risk of ovarian cancer above 50%.) Also like Jolie, I chose to get a double mastectomy to reduce my risk of breast cancer to less than 5%. In 2007, I wrote a first-person story in the Los Angeles Times about finding out I had this mutation and how I decided what to do about it. Jolie is an icon of beauty -- and her disclosure doesn't change that.
HEALTH
October 1, 2011 | By Jill U. Adams, Special to the Los Angeles Times
What's the case for environmental pollutants contributing to breast cancer? Circumstantial evidence keeps patients, doctors, advocates and scientist asking this question, but so far no clear relationship between exposure and disease has been shown in people. Known risks for breast cancer include family history, mutations in the BRCA1 and BRCA2 genes, a woman's reproductive history — the age at which she gets her first period, the number of children she has and when she enters menopause — and lifestyle factors such as cigarette and alcohol use, diet and exercise.
NEWS
July 25, 2012 | By Rosie Mestel, Los Angeles Times
Maybe you've been reading a lot lately about the development of fetal DNA tests based on a curious fact -- that the blood of a pregnant woman contains tiny bits of DNA of the fetus. Several groups have recently used this fact to sequence the entire genome of a fetus and pick up the presence of extra chromosomes or even individual gene variants that would render the baby prone to health conditions. It's an important development with much promise, health researchers say, because it offers a way to detect genetic abnormalities very early, without the small but real risk of miscarriage that comes with today's widely used screening technologies: amniocentesis and chorionic villus sampling.
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