April 23, 2013 |
Way back in 2002, Dr. Judah Folkman hit upon a tantalizing weight-loss strategy for obese mice. When given daily injections of a drug designed to fight cancer, their fat melted away. The higer the dose they got, the more fat they lost. Some of the obese mice shed so much weight that they wound up at “near normal body weights,” Folkman and his colleagues reported in this article in Proceedings of the National Academy of Sciences. Whatever happened to this promising fat-busting drug?
March 21, 2013 |
A compounding company in Augusta, Ga., has recalled syringes of the cancer drug Avastin it supplied over five months to physicians treating vision problems after the Food and Drug Administration received word that five patients who received the compounded medication came down with eye infections that could leave them blind. The FDA announced the recall Thursday after regulators conducted a preliminary inspection of Clinical Specialties Compounding Pharmacy and found "practices at the site that raise concerns about a lack of sterility assurance.
October 24, 2012 |
If a medical study seems too good to be true, it probably is, according to a new analysis. In a statistical analysis of nearly 230,000 trials compiled from a variety of disciplines, study results that claimed a "very large effect" rarely held up when other research teams tried to replicate them, researchers reported in Wednesday's edition of the Journal of the American Medical Assn. "The effects largely go away; they become much smaller," said Dr. John Ioannidis, the Stanford University researcher who was the report's senior author.
May 31, 2012
When you take medicine, there's a good chance you're getting a dose of modern global business practices as well. Eighty percent of the active ingredients in the medications that Americans use are produced overseas. In a single drug, it's quite possible that the individual components came from several countries and were assembled in yet another before arriving on U.S. shores. This diffuse manufacturing operation increases the opportunities for chicanery, which can include too-low amounts of active ingredients or substitution of different ingredients as well as adulterated ones.
February 9, 2012 |
A drug that has been approved for the treatment of a type of skin cancer since 1999 appears to reverse Alzheimer's symptoms -- in mice. Case Western Reserve University School of Medicine neuroscientist Gary Landreth and colleagues reported Thursday that bexarotene quickly cleared away beta-amyloid plaque, believed to cause the cognitive deficits of Alzheimer's disease, from the brains of genetically engineered mice. Mice who received bexarotene...
January 26, 2012 |
Biotech giant Amgen is hoping to bolster its cancer drug pipeline by buying fellow drug developer Micromet Inc. for $1.16 billion. At $11 a share, with an Amgen subsidiary buying the majority of Micromet's stock and then the Amgen parent company picking up the rest, the price represents a 33% premium on Micromet's closing price Wednesday. Thousand Oaks-based Amgen is itself among the world's premier drug makers but hasn't had many popular drugs in years. Rockville, Md.-based Micromet, meanwhile, is testing a promising treatment for leukemia and non-Hodgkin's lymphoma.