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NEWS
October 11, 2010
Make way for the future, at least when it comes to stem-cell therapy. An Atlanta hospital treated the first patient Friday in a nationwide clinical trial of a therapy derived from embryonic stem cells. The clinical trial, run by pharmaceutical company Geron Corp., seeks to test whether experimental cells, known as GRNOPC1, are safe for use in humans and whether patients will regain neuromuscular control in their legs and torsos. The Shepherd Center in Atlanta, a rehabilitation hospital that specializes in people who have spinal cord injuries or disease, and Northwestern Medicine in Chicago are currently enrolling patients in the trial.
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SCIENCE
September 27, 2008 | From Times Staff and Wire Reports
Treatment with genetically modified stem cells helped rats with a paralyzing disease live significantly longer, U.S. researchers said this week. Rats with amyotrophic lateral sclerosis, or Lou Gehrig's disease, that were treated with the gene-engineered stem cells lived 28 days longer than untreated mice, the researchers told a conference. The injection contained adult nerve stem cells that were engineered to release a growth factor called glial cell-line derived neurotrophic factor, or GDNF.
SCIENCE
June 19, 2005 | By Alan Zarembo, Times Staff Writer
The courier arrived just after midnight with a bag of blood collected from a fresh umbilical cord. Inside the laboratory at Family Cord Blood Services in Santa Monica, a worker siphoned off red cells, leaving a dilute mixture of stem cells — a personal supply for Olivia Michelle Boyd, born 15 hours earlier in Honolulu. Her parents, Stephanie and Anthony Boyd, had agreed to pay the company $1,265 to harvest the material and $115 a year to preserve it in a stainless steel tank filled with liquid nitrogen.
CALIFORNIA | LOCAL
October 1, 1990 | From Times staff and wire reports
Researchers at an American Red Cross research laboratory in Bethesda, Md., have succeeded in greatly extending the life span of human cells grown in the laboratory, a feat that promises to shed new insight on the aging process. Researchers have long known that human cells grown in a test tube can reproduce no more than 60 times before they die from old age--that somehow the cells are genetically programmed to die after that number of generations has been achieved.
SCIENCE
October 11, 2008 | From Times Staff and Wire Reports
The University of Minnesota has concluded that falsified data were used in a 2001 article published by one of its researchers that suggested adult stem cells could be used as an alternative to embryonic stem cells in medical research. The school is asking that the article be retracted. An investigation into research published by Dr. Catherine Verfaillie cleared her but pointed to a former graduate student, Dr. Morayma Reyes, for altering data by adjusting brightness and contrast in images used in the article.
NEWS
December 16, 1988 | THOMAS H. MAUGH II, Times Science Writer
Researchers at UC San Diego using a gene replacement technique have taken a major step toward the development of a new form of cancer therapy. A team headed by molecular biologist Wen-Hwa Lee has for the first time converted cancer cells grown in a laboratory into healthy cells by replacing a defective gene with a normal gene.
NEWS
January 14, 1998 | TERENCE MONMANEY, TIMES MEDICAL WRITER
Breaking a biological barrier once thought out of reach, scientists for the first time have apparently endowed healthy human cells growing in a dish with a quality that alchemists, explorers and mystics have vainly sought for ages: immortality. In the new research, due to be published Friday in the journal Science, the scientists genetically altered cells, enabling them to keep dividing long past their allotted life span.
OPINION
May 27, 2005
Re "House Defies the President on Stem Cells," May 25: When the president on Tuesday welcomed 21 families to the White House, all with children from embryos donated by other couples, I couldn't help but see there were some people missing: those with spinal cord injuries, cancer patients and the rest who could benefit from more extensive stem cell research. Is George Bush afraid he might catch some truth? Jim Geezil Agua Dulce Embryos apparently need to be saved by George Bush and House Majority Leader Tom DeLay in order to protect the "cycle of life."
NEWS
April 14, 2011 | By Thomas H. Maugh II, Los Angeles Times
Workers at the Fukushima Daiichi nuclear power plant in Japan should have their blood stem cells collected and stored in case the workers are exposed to excess radiation and require medical treatment during the shutdown and cleanup necessitated by the magnitude 9 Tohoku earthquake and the tsunami that followed it, Japanese physicians said Thursday. Bone marrow transplants are a common treatment method for such exposures, but they can be time-consuming when a search has to be made for matching donors and the recipients then have to take immunosuppressive drugs for the rest of their lives.
CALIFORNIA | LOCAL
December 28, 2009 | Thomas H. Maugh II
Dr. Edwin G. Krebs, the University of Washington Nobel laureate who co-discovered the mechanism by which a wide variety of processes are turned on and off within cells and thereby led to an explosion of knowledge about how cells grow, change, divide and die, died Dec. 21 in Seattle from progressive heart failure. He was 91. Krebs and his co-laureate Edmond H. Fischer discovered that most processes within cells -- ranging from fundamental metabolic reactions to the initiation of cancer -- are triggered when key proteins are activated by a process called phosphorylation, in which a phosphate molecule is added to the protein.
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