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August 14, 2004 | From Times Staff and Wire Reports
A new type of drug can reduce cholesterol levels significantly, the makers of the drug reported Wednesday. The drug works through a genetic method called anti-sense, said Carlsbad, Calif.-based Isis Pharmaceuticals. Known by its experimental name, ISIS 301012 blocks production of a protein that carries low-density lipoprotein, the so-called bad cholesterol that causes heart disease. In 19 volunteers, the drug lowered LDL levels by as much as 44% after 25 days.
For almost 52 million Americans with high cholesterol, the complex causes of heart disease were long ago reduced to a simple formula of good cholesterol and bad cholesterol. The higher the ratio of good cholesterol to bad cholesterol, the greater the chances of staying healthy. Now experiments with genetically engineered mice show that some high-density lipoproteins--the so-called good HDL cholesterol long thought to prevent heart disease--may cause it.
July 1, 2007 | From Times Wire Services
Kroger Co., the nation's largest traditional grocery company and operator of the Ralphs chain in Southern California, is marketing a new milk brand for its cholesterol-reducing potential. The product, under Kroger's Active Lifestyle brand, is billed as the first national launch of a cholesterol-cutting milk. It adds to Kroger's expanding lines for consumers of health-conscious and natural or organic foods and the in-house brands that the company sees as an important part of its profit strategy.
August 3, 1995 | From Newsday
Eating tofu and other soybean products can significantly reduce cholesterol levels, scientists said Wednesday. Six weeks to three months of substituting soybeans for animal proteins cut total blood cholesterol by an average of 9.3%, a University of Kentucky team reports in today's issue of the New England Journal of Medicine. The researchers analyzed 38 previous clinical studies with a total of 740 subjects, going back 18 years.
December 9, 1988 | MARK A. STEIN, Times Staff Writer
Scenic bayside Sausalito, where posh waterfront restaurants serve up spectacular views of San Francisco as well as fish dishes swimming in Hollandaise sauce, labeled itself the nation's first "cholesterol-free zone" Thursday.
January 16, 1997 | From Times staff and wire reports
Aggressively lowering cholesterol in people who have had bypass operations can help prevent their arteries from reclogging, according to a multicenter study. About 400,000 Americans have bypasses each year to reroute blood around clogged heart arteries, but the patients often need repeat surgery when the arteries clog up again. In a study of 1,351 patients who had undergone bypasses, half received very aggressive treatment to reduce cholesterol and half received only moderate treatment.
November 19, 1990 | From Times staff and wire reports
Hostile teen-agers are likely to grow up to be adults who have high cholesterol, according to a study that finds new links between anger and heart trouble. For years, many experts assumed that hard-driving, impatient people with classic Type A personalities were at high risk of heart attacks. But many of the researchers have grown skeptical of this theory, and some now believe that the truly lethal personality trait is hostility and anger.
What's your cholesterol? That question, says Robert Kowalski, has become the '90s equivalent of "What's your sign?" As author of the former bestseller "The 8-Week Cholesterol Cure" (Harper & Row) Kowalski is partly responsible for making the waxy, fatty substance a household word. Thanks to low-cost screenings available everywhere from drugstores to shopping malls to county fairs, these days it's as easy for people to find out their cholesterol level as it is their blood type.
June 23, 2005 | From Bloomberg News
Pfizer Inc. may limit patient choices by developing its newest cholesterol drug only in combination with its bestselling Lipitor product, according to an article in a leading medical journal. Pfizer is developing a pill that lowers LDL, the so-called bad cholesterol, and raises HDL, the "good" cholesterol, by combining Lipitor with its experimental torcetrapib compound.
November 5, 1990 | From Times staff and wire reports
A Michigan researcher has used gene therapy in rabbits to correct an inherited disorder, characterized by high levels of cholesterol, that is a primary contributor to heart disease in humans. The finding potentially opens the door to a new era in treating hardening of the arteries and liver disease. The rabbits have a genetic defect called familial hypercholesterolemia.
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