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BUSINESS
February 6, 2008 | From Times Wire Services
Watson Pharmaceuticals Inc. will begin shipping generic versions of Merck & Co.'s osteoporosis drug Fosamax. Merck will make and supply the drug and receive a share of the profit in the U.S., Corona-based Watson said. Sales of Fosamax dropped 3% to $3 billion last year, Whitehouse, N.J.-based Merck reported Jan. 30. The drug is expected to lose market exclusivity at the close of business today, according to Watson.
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NEWS
February 22, 2011 | By Shari Roan, Los Angeles Times
Osteoporosis drugs known as bisphosphonates have pros and cons that should be carefully considered by doctors and their patients, according to a new study assessing their impact. The medications, which include the brands Fosamax and Reclast, clearly reduce the risk of typical fractures caused by osteoporosis such as breaks in the hip and spine. However, the new study clarifies recent findings that the drugs increase the risk of other types of fractures. These so-called "atypical" fractures occur in the femur and in the bone just below the hip joint.
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HEALTH
February 22, 2010 | By Joe Graedon, Teresa Graedon, The People's Pharmacy
Is there a way to make passing a kidney stone less painful? I went from uncomfortable to unbearable pain within hours. The ER doctors gave me narcotic pain relievers but nothing to speed the stone out. If surgery is not needed to remove the stone, Flomax (tamsulosin), the drug used to ease symptoms of prostate enlargement, may facilitate passage of kidney stones (Current Opinion in Urology, March 2008). Shock-wave treatment (lithotripsy) is sometimes used to break kidney stones into smaller pieces.
HEALTH
May 17, 2010 | Joe Graedon, Teresa Graedon, The People's Pharmacy
Q: I published the original article on cranberry juice cocktail and urinary tract infections (Journal of Urology, May 1984). We also demonstrated in several nursing home studies that cranberry juice cocktail, not the plain juice, works best. Please spare your readers the tartness of the straight juice. — Anthony E. Sobota, PhD A: Thank you for investigating this old wives' tale in such a scientific manner. Investigators have confirmed your original findings and explored why it works (Urology online, April 16, 2010)
NEWS
October 9, 1995 | SHARI ROAN
What's new in the treatment of osteoporosis? Fosamax. Approved last week, Fosamax is the first new drug for osteoporosis in 20 years. The drug, chemically known as alendronate, helps to increase bone density. Calcitonin nasal spray. The hormone calcitonin, now available as an injectable medication, may soon be approved as a nasal spray. The medication helps slow the rate of bone loss. Sodium fluoride. An experimental regimen using a slow-release form of the chemical has shown promise in increasing bone strength and reducing the risk of fracture.
HEALTH
April 17, 2006
Re "Bone Drugs' Reverse Danger" [April 3]: A year ago, at age 67, I was prescribed Fosamax to treat beginning signs of osteoporosis. After the first dose, my neck and my thumbs became stiff and sore. After the second dose, my neck was so stiff that I was unable to drive because I couldn't turn my head. My thumbs were sore and swollen -- the doctor referred to them as "arthritis thumbs." However, the worst symptom was a burning sensation across the back of my scalp that was so severe I couldn't rest my head against a pillow and had to sleep sitting up. I stopped the medication.
HEALTH
May 17, 2010 | Joe Graedon, Teresa Graedon, The People's Pharmacy
Q: I published the original article on cranberry juice cocktail and urinary tract infections (Journal of Urology, May 1984). We also demonstrated in several nursing home studies that cranberry juice cocktail, not the plain juice, works best. Please spare your readers the tartness of the straight juice. — Anthony E. Sobota, PhD A: Thank you for investigating this old wives' tale in such a scientific manner. Investigators have confirmed your original findings and explored why it works (Urology online, April 16, 2010)
CALIFORNIA | LOCAL
September 12, 1996 | From Times staff and wire reports
Fosamax, the first drug developed in 20 years to treat osteoporosis, also prevents the bone-thinning disease, according to a report presented Wednesday at a meeting of the American Society for Bone and Mineral Research. The two-year study, led by Dr. Michael McClung of the Oregon Osteoporosis Center in Portland, involved 1,609 women ages 45 to 59 who had been through menopause but had not suffered any fractures. The results showed that women taking Fosamax had a 3.
HEALTH
July 20, 2009 | Joe Graedon and Teresa Graedon
My doctor just prescribed Prevacid for acid reflux. I am reluctant to take this medicine because I have heard it might lead to weakened bones. I already have severe osteoporosis because of a lengthy course of cortisone. This drug caused significant bone loss, so I am now taking Fosamax. I would hate to undo the benefits I have gotten on Fosamax, but the drug does cause bad heartburn. I feel caught in a dilemma. A surprising number of medicines have a negative effect on bone density.
SCIENCE
August 12, 2009 | Thomas H. Maugh II
The first member of a new class of osteoporosis drugs reduced spinal fractures by about two-thirds in post-menopausal women and in men undergoing hormone-deprivation therapy for prostate cancer, according to two studies released online today by the New England Journal of Medicine. The drug, called denosumab, is the first to block production of cells called osteoclasts that break down bones, and physicians have high hopes for it because of its efficacy, ease of administration and apparent lack of severe side effects.
HEALTH
February 22, 2010 | By Joe Graedon, Teresa Graedon, The People's Pharmacy
Is there a way to make passing a kidney stone less painful? I went from uncomfortable to unbearable pain within hours. The ER doctors gave me narcotic pain relievers but nothing to speed the stone out. If surgery is not needed to remove the stone, Flomax (tamsulosin), the drug used to ease symptoms of prostate enlargement, may facilitate passage of kidney stones (Current Opinion in Urology, March 2008). Shock-wave treatment (lithotripsy) is sometimes used to break kidney stones into smaller pieces.
SCIENCE
August 12, 2009 | Thomas H. Maugh II
The first member of a new class of osteoporosis drugs reduced spinal fractures by about two-thirds in post-menopausal women and in men undergoing hormone-deprivation therapy for prostate cancer, according to two studies released online today by the New England Journal of Medicine. The drug, called denosumab, is the first to block production of cells called osteoclasts that break down bones, and physicians have high hopes for it because of its efficacy, ease of administration and apparent lack of severe side effects.
HEALTH
July 20, 2009 | Joe Graedon and Teresa Graedon
My doctor just prescribed Prevacid for acid reflux. I am reluctant to take this medicine because I have heard it might lead to weakened bones. I already have severe osteoporosis because of a lengthy course of cortisone. This drug caused significant bone loss, so I am now taking Fosamax. I would hate to undo the benefits I have gotten on Fosamax, but the drug does cause bad heartburn. I feel caught in a dilemma. A surprising number of medicines have a negative effect on bone density.
HEALTH
January 12, 2009 | Jill U. Adams
Two recent reports have linked the osteoporosis drug alendronate (Fosamax) with rare but serious side effects. In a letter to the New England Journal of Medicine published Jan. 1, a Food and Drug Administration official reported that since Fosamax was first marketed in 1995, 23 cases of esophageal cancer in patients taking the drug -- including eight deaths -- have been reported to the agency. And a USC study published in the January issue of the Journal of the American Dental Assn.
SCIENCE
January 3, 2009 | Thomas H. Maugh II
The family of bone-strengthening drugs called bisphosphonates -- best known by the brand names Fosamax, Actonel and Boniva -- pose a small risk of causing esophageal cancer, a Food and Drug Administration official reported Thursday in a letter to the New England Journal of Medicine. Diane K. Wysowski of the drug risk assessment division said the FDA has received 23 reports of the cancer developing in patients taking Fosamax, manufactured by Merck & Co. Eight of the patients died.
BUSINESS
February 7, 2008 | From the Associated Press
At least three generic versions of the popular osteoporosis treatment Fosamax are headed for pharmacy shelves with the expiration of the drug's main patent Wednesday, bringing patients hefty savings. Two of the biggest makers of generic drugs, Teva Pharmaceutical Industries Ltd. and Barr Pharmaceuticals Inc., said Wednesday they would immediately begin selling generic Fosamax, which is made by Merck & Co.
NEWS
February 22, 2011 | By Shari Roan, Los Angeles Times
Osteoporosis drugs known as bisphosphonates have pros and cons that should be carefully considered by doctors and their patients, according to a new study assessing their impact. The medications, which include the brands Fosamax and Reclast, clearly reduce the risk of typical fractures caused by osteoporosis such as breaks in the hip and spine. However, the new study clarifies recent findings that the drugs increase the risk of other types of fractures. These so-called "atypical" fractures occur in the femur and in the bone just below the hip joint.
BUSINESS
February 7, 2008 | From the Associated Press
At least three generic versions of the popular osteoporosis treatment Fosamax are headed for pharmacy shelves with the expiration of the drug's main patent Wednesday, bringing patients hefty savings. Two of the biggest makers of generic drugs, Teva Pharmaceutical Industries Ltd. and Barr Pharmaceuticals Inc., said Wednesday they would immediately begin selling generic Fosamax, which is made by Merck & Co.
BUSINESS
February 6, 2008 | From Times Wire Services
Watson Pharmaceuticals Inc. will begin shipping generic versions of Merck & Co.'s osteoporosis drug Fosamax. Merck will make and supply the drug and receive a share of the profit in the U.S., Corona-based Watson said. Sales of Fosamax dropped 3% to $3 billion last year, Whitehouse, N.J.-based Merck reported Jan. 30. The drug is expected to lose market exclusivity at the close of business today, according to Watson.
HEALTH
August 21, 2006 | From Times wire reports
The Merck and Co. drug Fosamax does a better job at preventing bone deterioration than vitamin D for people using steroids to treat arthritis, a study recently showed. Fosamax was found to increase the density of bones in the spine by just more than 2% in the 100 volunteers who received it along with steroids for 18 months, the study said.
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