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Fragile X Syndrome

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NEWS
November 10, 1996 | Associated Press
The National Institute of Child Health and Human Development is offering a free booklet on Fragile X syndrome, the most common genetically inherited form of mental retardation. The gene that causes the syndrome was only discovered in 1991. The booklet contains information on the physical and behavioral characteristics of children with Fragile X, the types of mental and language disabilities that the children experience, and ways of dealing with these issues.
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SCIENCE
September 20, 2012 | By Alan Zarembo, Los Angeles Times
An experimental drug can improve sociability in patients with fragile X syndrome and may be helpful as a treatment for autism, according to the authors of a new study. Fragile X is a rare genetic disorder that affects about 1 in 4,000 boys and 1 in 8,000 girls, according to the National Institutes of Health. It usually results in mental retardation and - in about half of cases - some form of autism. In fragile X, which accounts for 2% of autism cases, a mutation in a gene on the X chromosome turns off production of a regulatory protein known as FMRP.
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SCIENCE
September 20, 2012 | By Alan Zarembo, Los Angeles Times
An experimental drug can improve sociability in patients with fragile X syndrome and may be helpful as a treatment for autism, according to the authors of a new study. Fragile X is a rare genetic disorder that affects about 1 in 4,000 boys and 1 in 8,000 girls, according to the National Institutes of Health. It usually results in mental retardation and - in about half of cases - some form of autism. In fragile X, which accounts for 2% of autism cases, a mutation in a gene on the X chromosome turns off production of a regulatory protein known as FMRP.
ENTERTAINMENT
June 21, 2009
Your story on Ayelet Waldman's book "Bad Mother" ["A Real Mother of a Job," June 14] continues a recent spate of articles on her and interviews with her, many focusing on her views on abortion. I am the mother of a 23-year-old son with fragile X syndrome, a condition that caused, in the words of Waldman, a "mentally retarded person." Her casual use of this term, together with a press that seems to think it's OK for people to use such derogatory language to describe mentally disabled people, concerns me. Are we ready to respect people who use sexist language and racial slurs?
CALIFORNIA | LOCAL
February 18, 1991 | From Times Staff and Wire Reports
A genetic discovery may pave the way for better tests to determine if an unborn baby will inherit a common form of mental retardation, French researchers said last week. They reported in the journal Nature that they have found new genetic features of Fragile X syndrome--the second most common type of inherited mental retardation after Down's syndrome--that may help improve genetic counseling for the disorder.
CALIFORNIA | LOCAL
December 15, 1991 | DENIS M. SEARLES, ASSOCIATED PRESS
In 1983, Jeannie Lancaster was worried about her oldest son's slow development, and her pediatrician urged having the boy tested for Fragile X Syndrome, a little-known and incurable form of inherited mental retardation. "We were aware of significant problems with our oldest son and had been looking for an answer because we were seeing similarities in our younger son," Lancaster said. "Our pediatrician attended a seminar on genetic conditions where Fragile X was presented.
ENTERTAINMENT
June 21, 2009
Your story on Ayelet Waldman's book "Bad Mother" ["A Real Mother of a Job," June 14] continues a recent spate of articles on her and interviews with her, many focusing on her views on abortion. I am the mother of a 23-year-old son with fragile X syndrome, a condition that caused, in the words of Waldman, a "mentally retarded person." Her casual use of this term, together with a press that seems to think it's OK for people to use such derogatory language to describe mentally disabled people, concerns me. Are we ready to respect people who use sexist language and racial slurs?
NEWS
May 30, 1991 | THOMAS H. MAUGH II, TIMES SCIENCE WRITER
U.S. and Dutch researchers have discovered the defective gene that causes fragile X syndrome, the most common form of inherited mental retardation. The report of the discovery, which will be published Friday in the journal Cell, is exciting to researchers because it offers for the first time the ability to perform prenatal screening for the disorder, and may eventually lead to the discovery of new ways to treat it. The syndrome affects one in every 1,250 males and one in every 2,000 females.
SCIENCE
February 6, 2014 | By Geoffrey Mohan
A generic blood pressure drug could prevent hyperactive brain cell firing associated with early stages of autism spectrum disorder, according to a new study. Injecting pregnant mice with Bumetanide, a diuretic, appears to correct a developmental switch flipped during childbirth that reverses the firing characteristics of neurons in newborns, according to a study published online Thursday in the journal Science. Bumetanide mimics the effects of oxytocin, a hormone released during labor that helps protect newborns from the stresses and complications of birth, the study found.
SCIENCE
June 3, 2013 | By Geoffrey Mohan
Hyperactive brain cells firing together could be an early indicator of autism and developmental disabilities, a team of UCLA researchers has found. Networks of neurons were found to be firing in a highly synchronized and seemingly unrelenting fashion, even through sleep, in the brains of juvenile mice that have a genetic abnormality similar to one that causes mental retardation and autism symptoms in humans, according to the research published online Monday in Nature Neuroscience.
NEWS
November 10, 1996 | Associated Press
The National Institute of Child Health and Human Development is offering a free booklet on Fragile X syndrome, the most common genetically inherited form of mental retardation. The gene that causes the syndrome was only discovered in 1991. The booklet contains information on the physical and behavioral characteristics of children with Fragile X, the types of mental and language disabilities that the children experience, and ways of dealing with these issues.
CALIFORNIA | LOCAL
December 15, 1991 | DENIS M. SEARLES, ASSOCIATED PRESS
In 1983, Jeannie Lancaster was worried about her oldest son's slow development, and her pediatrician urged having the boy tested for Fragile X Syndrome, a little-known and incurable form of inherited mental retardation. "We were aware of significant problems with our oldest son and had been looking for an answer because we were seeing similarities in our younger son," Lancaster said. "Our pediatrician attended a seminar on genetic conditions where Fragile X was presented.
NEWS
May 30, 1991 | THOMAS H. MAUGH II, TIMES SCIENCE WRITER
U.S. and Dutch researchers have discovered the defective gene that causes fragile X syndrome, the most common form of inherited mental retardation. The report of the discovery, which will be published Friday in the journal Cell, is exciting to researchers because it offers for the first time the ability to perform prenatal screening for the disorder, and may eventually lead to the discovery of new ways to treat it. The syndrome affects one in every 1,250 males and one in every 2,000 females.
CALIFORNIA | LOCAL
February 18, 1991 | From Times Staff and Wire Reports
A genetic discovery may pave the way for better tests to determine if an unborn baby will inherit a common form of mental retardation, French researchers said last week. They reported in the journal Nature that they have found new genetic features of Fragile X syndrome--the second most common type of inherited mental retardation after Down's syndrome--that may help improve genetic counseling for the disorder.
NEWS
August 31, 2010
Parents of children with fragile X syndrome reported improvements in their children's attention spans and communication skills as well as decreased anxiety after the children were given the antibiotic minocycline, researchers said Tuesday. The results were strictly observational and were uncontrolled, but they suggest the drug -- which is already used widely for treating teen acne -- might also have a use for the fragile X condition. The results were sufficiently promising that the National Fragile X Foundation is now sponsoring a preliminary clinical trial.
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