February 15, 2000 |
The University of Pennsylvania admitted some mistakes in a gene therapy experiment that killed a teenage volunteer in September, promising improvements but denying liability for the death of Jesse Gelsinger, 18.
October 29, 2009 |
A new gene therapy procedure to restore function in lungs damaged during harvesting from donors could make more of the organs available for transplanting, Canadian researchers reported Wednesday. Currently, only about 15% of potential donor lungs are used because the rest are too damaged to implant. The new technique, which has not yet been tested in humans, could prevent that damage or even reverse it, potentially expanding the supply of lungs sharply. Lung transplants are the definitive therapy for many end-stage lung diseases such as emphysema and cystic fibrosis, but they are fraught with problems.
February 23, 1990 |
Scientists sought permission today for the first attempt at human gene therapy--research that will involve children stricken by a rare, inherited immune disorder that has forced some to live in plastic bubbles. In a proposal filed with federal review committees, National Institutes of Health researchers said they want to correct the children's illness, caused by the failure of a defective gene to make a vital enzyme, by inserting correct copies of the gene into their white blood cells.
January 31, 2000 |
A Harvard-affiliated hospital in Boston quietly suspended a gene therapy experiment last summer after three of the first six patients died and a seventh fell seriously ill, previously unreleased research records show. Richard Junghans, the Harvard Medical School researcher who led the study, blamed the problems on a series of tragic coincidences that were mostly not related to the treatment.
November 4, 2000 |
The University of Pennsylvania announced it had reached an out-of-court settlement with the family of Jesse Gelsinger, a Tucson man whose death in a gene therapy experiment 14 months ago prompted a national reassessment of protections for research volunteers. Details of the settlement, which grew out of a civil suit the family filed in a Pennsylvania state court in September, were not disclosed. Gelsinger, who was 18 and who had an inherited liver disorder, died Sept.
January 1, 1999 |
Researchers in Pennsylvania said Thursday that they have taken a vital step toward real gene therapy by designing a special gene that can be turned on and off as needed, and by making it work in live animals. Dr. James Wilson and his colleagues at the University of Pennsylvania School of Medicine said they have specifically tailored a genetic system so that it can be controlled from outside the animal, simply by giving doses of a drug, rapamycin.
November 12, 2002 |
Gene therapy has become a science of irony and unintended consequences. Through its decades of development, the once-glamorous child of the genetic revolution has faced bad press, lackluster results and a tragic death. Now, fast on the heels of its first-ever success -- and one of its biggest disappointments -- the field is having to reevaluate its use of a principal method of inserting therapeutic genes into cells.
CALIFORNIA | LOCAL
May 13, 1987 |
A group of researchers in San Diego has successfully transplanted foreign genes into liver cells, raising the possibility of eventually treating hemophilia and other genetic disorders of the liver through the emerging techniques of gene therapy. Their report of the work, to be published later this month in the Proceedings of the National Academy of Sciences, is the first published instance of successful introduction and expression of foreign genes in liver cells.
January 17, 2004 |
Two children who developed leukemia after receiving gene therapy may have been victims of a rare combination of genes, a team from the National Cancer Institute reported in the Jan. 16 issue of Science. Dr. Utpal P. Dave and his colleagues discovered that IL2RG, the gene used to treat the children, could combine with another gene called Lmo2 to cause leukemia in mice. The children were being treated for an inherited disease.
April 7, 2001 |
Participants in some gene therapy trials should be closely followed for up to 20 years after a study's completion to guard against future complications, a U.S. advisory group said Friday. Currently only organ transplant recipients are monitored that long, but Food and Drug Administration advisors said so little was known about the long-term consequences of gene therapy that it was better to err on the side of caution.