March 24, 1993 |
After the longest and most frustrating search in the annals of molecular biology, an international team of researchers has located the defective gene that causes Huntington's disease, a crippling disorder that afflicts about 30,000 Americans. The discovery will immediately make possible cheaper and more accurate tests to identify people who will develop Huntington's.
CALIFORNIA | LOCAL
January 10, 1998 |
Marianne Whitmyer first noticed the changes in her fingers and her tongue. They looked the same but no longer worked the same, her fine motor control dissolving after two decades as a professional flutist. The problem, doctors discovered early last year, is that Whitmyer's brain is dying. Whitmyer, principal flute and soloist with the Irvine Symphony, suffers from Huntington's chorea, or Huntington's disease, a progressive hereditary illness that leads to death.
February 17, 2011 |
A study published Wednesday in Science Translational Medicine described a group of people in Ecuador, descended from Spanish Jews who fled the Inquisition and converted to Christianity, who lack genes that help process human growth hormone in the body. The mutation they share results in very short stature -- they grow to only about 3 or 4 feet tall -- and high infant mortality. But their bodies' inability to receive growth hormone also seems to protect this group from diabetes and cancer, the researchers reported -- adding that this suggested that for aging people with normal levels of hormonal activity, less and not more human growth hormone may be best.
February 10, 1991 |
MY MOTHER'S brother, Uncle Paul, died when I was in 12th grade. While my mother was away at the funeral, my father took me out to dinner in Beverly Hills and tried to tell me about my uncle's illness--all my uncles' illnesses. My mother's three brothers had the same rare disorder, he said. It was hereditary: Huntington's disease. Then, perhaps fearing to tell dire news to someone so young, he assured me that our family would be fine.
October 28, 2001 |
A surprising and provocative study of brain tissue from people with Huntington's disease offers clues on how a defective gene causes the disorder and how it might be treated. About 30,000 Americans have HD, which generally appears between ages 30 and 45. It slowly hampers a person's ability to walk, think, talk and reason. Eventually, an affected person becomes totally dependent on others, and death usually follows from complications of the condition.
August 8, 1997 |
Four years after the discovery of the defective gene that causes Huntington's disease, researchers have produced the first clues about how the gene causes the devastating disorder. That new insight, experts say, could quickly lead to the first successful treatments not only for Huntington's, but also for half a dozen other diseases that have an identical genetic defect.