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September 17, 2008 | Tiffany Hsu, Times Staff Writer
Valencia biotechnology company MannKind Corp. thought it had encouraging news about its experimental insulin inhaler on Tuesday. But Wall Street wasn't buying it. For months, skeptical traders have expressed concern that the diabetes drug, if approved by the Food and Drug Administration, might end up with an FDA cancer advisory. Fears that the inhaler would never take off were still lurking Tuesday, even though MannKind said that trials of its Technosphere insulin delivery system showed no elevated cancer risk.
In 1922, Urvan Ubben's parents had his "funeral picture" taken, certain he would be the next family member to die of diabetes. Today, the 77-year-old laughs at the childhood photo and how he cheated death by being one of the first people to test insulin. Experts say he may be the world's oldest surviving diabetic. "I was one of the guinea pigs when Eli Lilly was trying to mass-produce insulin in Indianapolis back in 1922," Ubben said. "In those days, they figured that if you had diabetes, you didn't have a chance.
September 22, 2010
The basics In the simplest terms, diabetes means having too much glucose in your blood. Glucose is a type of sugar and a source of energy for the body. But if insulin, glucose’s “traffic cop,” isn’t doing its job, glucose accumulates in the bloodstream and all sorts of health problems can occur. Normally, most of the food a person eats gets converted into glucose, the body’s energy of choice. The circulatory system shuttles the glucose around so that hungry cells in the muscles, liver and elsewhere can snatch it out of the blood as it passes by. The liver cells are the hungriest for that glucose, because the liver is the body’s between-meal glucose storage facility.
July 17, 1989 | From staff and wire reports
Diabetics given a new pancreas to eliminate the need for insulin shots may also end up with healthier kidneys, six Minneapolis doctors reported last week in the New England Journal of Medicine. The discovery supports a long-held belief that if diabetics could carefully control their blood-sugar level, they might be able to avoid the kidney failure, blindness and other serious health problems that appear in many longtime sufferers of the disease.
October 26, 2009 | Marni Jameson
Simply put, diabetes is a contest between people and their blood. For people whose bodies don't produce enough insulin to manage their blood sugar, the goal is a normal blood score, achieved through a balancing act of lifestyle and medication. "Eventually most patients will follow a course of lifestyle, medications, then insulin," said Dr. Enrico Cagliero, referring to people diagnosed with the most common form of diabetes, known as Type 2. He's an endocrinologist at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School.
September 24, 1986 | MARCIDA DODSON, Times Staff Writer
In the first trial studies of their kind in the United States, diabetes specialists from UC Irvine and Johns Hopkins University have been given approval by the U.S. Food and Drug Administration to surgically implant insulin pumps, UCI officials said Tuesday.
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