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Mutation

ENTERTAINMENT
November 15, 1987
Hooray for Kristine McKenna and the Calendar section ("Julian Schnabel--Artist as Bad Boy," Nov. 1)! Four reasons: For the courage, maturity, tolerance and general big-heartedness to publish the (all-too-typical and apparently only) response to the article on Schnabel. For avoiding the comfort of cynicism and regionalism. For appreciating the possibly inspirational aspects of Schnabel's success. And for keeping us informed about the competition. EDWARD W. RANDELL JR. Sherman Oaks
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WORLD
July 16, 2010 | By John M. Glionna, Los Angeles Times
Inside a dimly lighted living room in the heart of the Javanese forest, Dede Koswara blankly examines his bulky hands, which have morphed to the size of catcher's mitts. He shuffles along on blackened, bloated feet, a prisoner of his own mutinous body. For years, the slender construction worker watched helplessly as his limbs broke out in a swath of grotesque bark-like warts that sapped his energy and limited his mobility. At one point, he seemed to sprout contorted yellow-brown branches 3 feet long.
NEWS
November 15, 2011 | By Shari Roan, Los Angeles Times / For the Booster Shots blog
Alcoholism and other substance-use disorders appear strongly linked to a particular gene mutation, researchers reported Tuesday. Substance-use disorders are thought to arise from a combination of environmental or lifestyle factors and genetic characteristics. Identifying certain genes that are known to predispose people to the disease could be helpful in preventing drug addiction. Researchers have been working to identify some of the prominent gene mutations that could serve as markers.
ENTERTAINMENT
April 23, 1999 | MARC WEINGARTEN
As the front man for Chicago art-rock collective the Sea and Cake, Sam Prekop blends musical idioms until they dissolve into one another and become indistinguishable. But no matter how far-flung his experiments, Prekop always places a high premium on crafting subtle, deceptively simple melodies that please through repetition. Which is why his sensibility is ideally suited to the kind of quasi-jazz material that the guitarist showcased at the Troubadour on Wednesday.
ENTERTAINMENT
February 2, 1996 | PHILIP BRANDES
When 8-year-old Rhoda calls Leroy, her decrepit apartment house janitor, "a very silly man," she's right on the money. But that's precisely the point--the sneering, black-toothed Leroy is played by a woman, Kris Strobeck, in Minneapolis-based Theatre 911's hilarious camp revival of Maxwell Anderson's "Bad Seed" at the St. Genesius Theatre. Then again, Rhoda has few grounds for complaint, seeing how this little sociopathic murderess is herself played by director Danny Schmitz, a 6-foot-tall man.
SCIENCE
May 14, 2013 | By Anna Gorman
Late Monday night, friends and colleagues started sending me Angelina Jolie's op-ed about her decision to have a double mastectomy. Like Jolie, I have the mutation in my BRCA1 gene that pushed my lifetime risk of developing breast cancer to nearly 90%. (It also raised my risk of ovarian cancer above 50%.) Also like Jolie, I chose to get a double mastectomy to reduce my risk of breast cancer to less than 5%. In 2007, I wrote a first-person story in the Los Angeles Times about finding out I had this mutation and how I decided what to do about it. Jolie is an icon of beauty -- and her disclosure doesn't change that.
NEWS
October 9, 2013 | By Mary MacVean
Scientists have discovered two gene mutations that they believe are associated with an increased risk of eating disorders. Anorexia nervosa and bulimia often run in families, but these eating disorders are complex, and it has proved difficult  to identify the paths. But, using two families with very high incidences of eating disorders, scientists say they found rare mutations, one in each family, that were associated with the people who had the disorders. The study suggests that mutations that decrease the activity of a protein that turns on the expression of other genes - called a transcription factor - increase the risk.
SCIENCE
October 25, 2003 | From Times Staff and Wire Reports
U.S. and Japanese researchers said Thursday they had found a genetic mutation that causes obsessive-compulsive disorder and other mental illnesses and said some patients had a second mutation that made their conditions more severe. The finding, reported in the journal Molecular Psychiatry, could make it easier to discover treatments for the disorder, one of the top 10 leading causes of disability worldwide.
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