August 24, 2012 |
A study this week reported that older men pass on more new mutations to their offspring than do younger men, a fact that could help explain higher rates of disorders such as autism, schizophrenia and others in kids born of older fathers. The same week, another article by the same group calculated that the mutation rate in fathers doubles between age 20 and age 58. Why fathers more than mothers? Because many of these mistakes happen as cells divide, and as we get older the rate of errors rises.
March 3, 2011 |
Two studies released Wednesday by the journal Nature show that work remains before so-called induced pluripotent stem (iPS) cells are ready for use in laboratory studies or clinical therapies. iPS cells are body cells that are programmed to unwind back into an embryonic state. Like embryonic stem cells, they have potential to develop into any other type of cell in the body. But they don't reprogram perfectly, researchers are showing. About a month ago, a team at the Salk Institute showed that iPS cells hold on to "memory" of their past identity.
October 9, 2013 |
Scientists have discovered two gene mutations that they believe are associated with an increased risk of eating disorders. Anorexia nervosa and bulimia often run in families, but these eating disorders are complex, and it has proved difficult to identify the paths. But, using two families with very high incidences of eating disorders, scientists say they found rare mutations, one in each family, that were associated with the people who had the disorders. The study suggests that mutations that decrease the activity of a protein that turns on the expression of other genes - called a transcription factor - increase the risk.
August 22, 2012 |
Men who become fathers later in life pass on more brand-new genetic mutations to their offspring, a study has found - probably contributing to disorders such as autism and schizophrenia in the next generation. The finding, published online Wednesday in the journal Nature , buttresses earlier observations that rates of autism and some other disorders are more prevalent in children born of older fathers, sometimes by a factor of two or more, experts said. Though this has been observed for years from population studies, scientists had not known what lay behind it. The new research, made possible by recent advances in DNA-sequencing technology, also should help correct an overemphasis on the riskiness of women giving birth at older ages, some researchers said.
June 8, 2011 |
Autism spectrum disorders can be caused by as many as 300 or so rare genetic mutations, scientists reported Wednesday. The research strongly implicates genetics, including spontaneous gene mutations, in the development of the disorder. But why do four times as many males as females develop autism spectrum disorder? In one of the three papers published in the journal Neuron , researchers suggest that girls are more resistant to gene mutations than boys. Girls seem to require a higher number of gene mutations to become afflicted with autism spectrum disorder.
November 19, 2010 |
Viruses possess an ability to mutate into strains that can render vaccines useless and become deadlier than their predecessor. But for a team of Texan scientists, this biological danger became a forensic asset that helped prosecutors convict two men accused of infecting close to a dozen women with HIV. In 2009, Philippe Padieu was sentenced in Texas to 45 years in prison for aggravated assault with a deadly weapon – the weapon, in this case,...