SCIENCE
July 9, 2008 | Thomas H. Maugh II, Times Staff Writer
Medical castration to treat localized prostate tumors does not prolong survival and its side effects far outweigh any potential benefit for most patients, researchers reported today. The technique, which involves using drugs to block the body's production of the male hormone androgen, is a powerful tool when used in conjunction with surgery or radiation for treating aggressive prostate tumors.
SCIENCE
July 18, 2012 | By Rosie Mestel, Los Angeles Times
Most patients diagnosed with early-stage prostate cancer will live just as long if they simply watch their cancers rather than have them surgically removed, according to the results of a landmark clinical trial that could upend the medical approach to a disease that affects 1 in 6 men. The study, which focused on cancers still confined to the prostate, should reassure patients who want to avoid distressing side effects of surgery - such as urinary incontinence...
SCIENCE
May 22, 2012 | By Rosie Mestel, Los Angeles Times
The PSA test should be abandoned as a prostate cancer screening tool, a government advisory panel has concluded after determining that the side effects from needless biopsies and treatments hurt many more men than are potentially helped by early detection of cancers. At best, one life will be saved for every 1,000 men screened over a 10-year period, according to the U.S. Preventive Services Task Force. But 100 to 120 men will have suspicious results when there is no cancer, triggering biopsies that can carry complications such as pain, fever, bleeding, infection and hospitalization.
HEALTH
December 19, 2011 | By Paul VanDevelder, Special to the Los Angeles Times
When my family doctor called five years ago with the news that my PSA levels had spiked, I hung up the phone and did what all of us do. I panicked. I thought, "So this is how I'm going to die. " Then came the delayed second reaction: This can't be right! I'm a teetotaling, nonsmoking, very fit middle-aged baby boomer, a husband and a father of a 13-year-old daughter. This just wasn't in the Tarot cards. Fortunately, I have five or six very close doctor friends, so I called one of them right away.
NEWS
May 23, 2012 | By Rosie Mestel, Los Angeles Times / For the Booster Shots blog
The PSA test should not be a routine screen for men of any age, the U.S. Preventive Services Task Force declared earlier this week. The assessment wasn't about saving money but was based on a review of the science on PSA screening -- what were the benefits and what were the harms? To recap: The task force concluded from two large studies that over a period of 10 years, one prostate cancer death at most was saved from PSA screening for every 1,000 men screened. The test finds many cancers that are not life-threatening, and treatment causes side effects from surgery and radiation such as impotence and urinary incontinence.
HEALTH
March 30, 2009 | Judy Foreman
Manny Hamelburg, 68, a retired businessman, had fought prostate cancer for years. First, he tried radiation, then a drug with side effects that nearly killed him, and finally Lupron, a drug that blocks production of testosterone, the hormone that can fuel prostate cancer. The cancer disappeared. But life was miserable. Without normal levels of testosterone, Hamelburg says, he had no energy, and "zero libido for seven years. I was like a eunuch. I was chemically castrated. Sex was just hugs."