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Protease Inhibitors

SCIENCE
February 14, 2003 | Thomas H. Maugh II, Times Staff Writer
Treatment of HIV-infected people with cocktails of anti-AIDS drugs has strongly increased survival, but a major new study shows that it also increases the risk of heart attacks, researchers said here Thursday. Clinicians have suspected as much for several years, but the study of nearly 24,000 patients provides the first strong evidence linking the treatment to myocardial infarctions. Every year patients take the drug cocktails increases their risk of heart attacks by 26%, Dr.
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CALIFORNIA | LOCAL
March 14, 1995 | JULIE MARQUIS, TIMES STAFF WRITER
Researchers hope to add years to the lives of AIDS patients by combining as many as three antiviral drugs and using new medications that ambush the virus in novel ways, experts said at a regional HIV conference Monday.
BUSINESS
April 30, 1997 | (Bloomberg News)
Agouron Pharmaceuticals Inc. has agreed to buy closely held Alanex Corp. for about $62 million in stock. Agouron said it will issue 1 million shares to pay for the drug-discovery company. The value of the transaction is based on Monday's closing share price of $62. San Diego-based Alanex uses its library of molecules to research treatments for pain, diabetes, obesity, anxiety and certain kinds of tumors. Agouron, based in La Jolla, develops drugs for treating cancer, AIDS and other diseases.
HEALTH
June 28, 1999 | THOMAS H. MAUGH II
A higher percentage of African Americans and Latinos are receiving AIDS care than was the case only a couple of years ago, but the gap between men and women is not closing nearly as rapidly, according to a new study by Rand researchers. The uninsured and those relying on Medicaid also received poorer care than those with private insurance, and patients who contracted the virus via intravenous drug use or heterosexual contact were less likely to receive adequate care than gay males, Dr. Martin F.
NEWS
March 1, 1996 | MARLENE CIMONS, TIMES STAFF WRITER
A federal advisory committee Thursday recommended government approval of a powerful new drug that recent research has shown can decrease or prevent AIDS-related complications and prolong life in very sick patients. The drug, ritonavir, developed by Abbott Laboratories, is one of a new class of potent antiviral drugs called protease inhibitors that has excited AIDS specialists.
CALIFORNIA | LOCAL
January 3, 1997 | LORI HAYCOX
Lorna Horn gets out of bed at 6:30 a.m. to shower and dress for school. Then she walks Dolly, the family's rambunctious Jack Russell terrier. These may not be big achievements for most 13-year-olds, but to Lorna and her parents, they are miraculous. A year ago, Lorna, who has AIDS, couldn't face mornings. Her stomach ached from the massive doses of drugs she took to stay alive. She didn't have the energy to shower, go to school or care for her dog. Often, she went to the hospital.
CALIFORNIA | LOCAL
February 4, 1998
Mortality rates among people with AIDS have been declining ever since a strikingly effective class of drugs, protease inhibitors, became available in 1993. Now, newly released figures paint a bright picture indeed: From 1996 to 1997, AIDS deaths declined by 44% in the United States and by 55% in Los Angeles.
NEWS
December 8, 1995 | From a Times Staff Writer
The Food and Drug Administration on Thursday formally approved the first of a new generation of powerful AIDS drugs, a family of compounds that appear at least 10 times more potent than the existing most widely prescribed antiviral therapies. The agency's approval of the first of those drugs, saquinavir, came in record time--only three months after the company applied for licensing and one month after an FDA advisory committee urged the agency to send it to the market.
NEWS
April 9, 2002 | From Associated Press
St. John's wort appears to interfere powerfully with a common cancer drug and can reduce its punch for weeks after people stop taking the herbal supplement, a study shows. St. John's wort is often taken as an over-the-counter remedy for mild depression, though its effectiveness has been questioned. Doctors also know the herb can interfere with the body's use of a variety of other medicines. In a small study released Monday, doctors showed that St.
NEWS
November 7, 1995 | Associated Press
The drug 3TC should be approved as the first new initial therapy to treat AIDS since AZT, scientific advisers told the Food and Drug Administration on Monday. A combination of 3TC and AZT boosted the immune system of patients and lowered the amount of HIV in their blood. But more significantly, the drug combination showed more effect in patients who had never taken AZT than in those who had taken AZT alone, as is standard for most patients, manufacturer Glaxo Wellcome said.
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