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Stem Cells

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SCIENCE
December 7, 2007 | Karen Kaplan, Times Staff Writer
Taking the next step in a series of breakthrough stem cell experiments, scientists have cured sickle cell anemia in mice by rewinding their skin cells to an embryonic state and manipulating them to create healthy, genetically matched replacement tissue.
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SCIENCE
April 17, 2014 | By Monte Morin
Scientists have replicated one of the most significant accomplishments in stem cell research by creating human embryos that were clones of two men. The lab-engineered embryos were harvested within days and used to create lines of infinitely reproducing embryonic stem cells, which are capable of growing into any type of human tissue. The work, reported Thursday in the journal Cell Stem Cell, comes 11 months after researchers in Oregon said they had produced the world's first human embryo clones and used them to make stem cells.
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OPINION
May 19, 2013
Re "Stem cells are made by cloning method," May 16 Cloning a human serves no purpose, so the arguments against making stem cells using a cloning method are ludicrous. On the other hand, cloning organs makes sense - the rest is just jibber-jabber from Luddites. Mike Benbrook El Cajon ALSO: Letters: Dying but not wanting to know Letters: Addiction treatment that works Letters: Election billboard ads may backfire
SCIENCE
April 9, 2014 | By Karen Kaplan
The Japanese stem cell scientist who was accused of misconduct by her own research institution apologized Wednesday for making careless mistakes but insisted that her STAP stem cells are real. Haruko Obokata told reporters at a news conference that she “produced the STAP cells successfully more than 200 times, and this is the truth,” according to the Yomiuri Shimbun's Japan News . The cells -- known formally as stimulus-triggered acquisition of pluripotency cells -- were described in a pair of studies published in January in the journal Nature.
SCIENCE
March 27, 2014 | Monte Morin
As new revelations further discredit a highly publicized Japanese study on the use of acid to create so-called STAP stem cells, scientists in the U.S. have quietly announced a research breakthrough that involves a more traditional means of producing the amazingly versatile cells. In a paper published Wednesday in the journal Nature, researchers said they had successfully generated embryonic stem cells using fertilized mouse embryos -- a feat that many scientists had thought was impossible.
NATIONAL
March 10, 2009 | Karen Kaplan
With the stroke of a pen, President Obama cleared the way Monday for the National Institutes of Health and other federal agencies to fund research using all kinds of human embryonic stem cells. "Scientists believe these tiny cells may have the potential to help us understand, and possibly cure, some of our most devastating diseases and conditions," Obama said at the signing ceremony. Obama's executive order removes funding restrictions put in place by President George W.
SCIENCE
July 24, 2009 | Thomas H. Maugh II
News that Chinese researchers have succeeded in growing healthy living mice from mouse skin cells takes scientists a significant step closer to human cloning, experts say, and is thus likely to reopen debate about the ethics of such reproductive techniques. The new feat -- in which animals were grown from cells that had been reverted back to their embryonic state -- is technically different from cloning. But the outcome is the same in both cases: a genetically identical copy of the donor animal.
SCIENCE
February 20, 2005 | By Alan Zarembo, Times Staff Writer
Alone at his computer, drool sliding down his chin, Tom Hill searched the Internet for anything that could save him. His 55-year-old body was gradually shutting down. His muscles twitched uncontrollably. He could no longer talk, so he scribbled notes to communicate with his wife, Valerie. Seven months earlier, he had been diagnosed with amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease — an incurable deterioration of the nervous system that spares the cognitive parts of the brain, leaving its victims sharply aware as they slowly die. The doctors told him there was no way to reverse the disease — no drugs, no surgeries, no other therapies.
NATIONAL
March 7, 2009 | Karen Kaplan and Noam N. Levey
Making good on a popular campaign pledge, President Obama will sign an executive order Monday rescinding restrictions on federal funding for human embryonic stem cell research, administration officials said Friday -- instantly making hundreds of millions of new dollars available for the controversial science.
SCIENCE
September 11, 2013 | By Eryn Brown
Researchers have reprogrammed cells inside living mice -- and have discovered that the pluripotent stem cells created in the process are even more flexible than those derived from embryos or grown in laboratory dishes. Someday the achievement might help scientists devise ways to treat human disease by directly regenerating tissues within human patients, said Manuel Serrano, an investigator at the Spanish National Cancer Research Center in Madrid and senior author of a study ( abstract here )
SCIENCE
April 1, 2014 | By Monte Morin
Research that made international headlines with a purported breakthrough in the creation of highly valuable stem cells has been found to contain falsified and manipulated data, according to a panel of Japanese investigators. At a news conference in Tokyo on Tuesday, the government's RIKEN research institute announced that it had concluded an investigation into allegations of misconduct, and found that the lead author of the study had improperly altered images of DNA fragments used in the research.
SCIENCE
March 27, 2014 | Monte Morin
As new revelations further discredit a highly publicized Japanese study on the use of acid to create so-called STAP stem cells, scientists in the U.S. have quietly announced a research breakthrough that involves a more traditional means of producing the amazingly versatile cells. In a paper published Wednesday in the journal Nature, researchers said they had successfully generated embryonic stem cells using fertilized mouse embryos -- a feat that many scientists had thought was impossible.
SCIENCE
March 14, 2014 | By Karen Kaplan and Monte Morin
The Japanese research institution at the center of a growing controversy over a new type of stem cells said Friday that its investigation of four scientists has confirmed two instances of "inappropriate" behavior but that neither case was severe enough to be considered intentional misconduct or outright fabrication of data. An investigative committee at RIKEN, which is funded primarily by the Japanese government, has been looking into charges that two high-profile papers published in January in the journal Nature included plagiarized material, duplicate photos and doctored figures.
SCIENCE
March 11, 2014 | Karen Kaplan
A number of scientists have been grumbling for weeks about a pair of breakthrough stem cell studies that seemed too good to be true. Now one of the senior researchers who worked on the papers agrees that they may be right. The studies, which were published in January by the journal Nature, described a surprisingly simple method of transforming mature cells into pluripotent stem cells capable of regenerating any type of tissue in the body. The key was to stress them out by soaking them in an acid bath for 30 minutes, prompting genetic changes that made the cells more flexible.
SCIENCE
January 29, 2014 | By Monte Morin
In a feat that experts say is a significant advance for regenerative medicine, scientists have discovered a surprisingly simple method for creating personalized stem cells that doesn't involve human embryos or tinkering with DNA. Two studies published Wednesday in the journal Nature describe a novel procedure for “reprogramming” the blood cells of newborn mice by soaking the cells in a mildly acidic solution for 30 minutes. This near-fatal shock caused the cells to become pluripotent, or capable of growing into any type of cell in the body.
CALIFORNIA | LOCAL
November 4, 2013 | By Larry Gordon
Thanks to a $100-million donation, UC San Diego will be creating a new clinical center to study how the use of stem cells may help cure or alleviate leukemia, spinal cord injuries, Alzheimer's disease and other health problems, officials announced Monday. The gift is from  T. Denny Sanford , a South Dakota businessman who made a fortune in the banking and credit card industry and has been very generous to various healthcare initiatives. The new Sanford Stem Cell Clinical Center at UC San Diego will integrate researchers affiliated with the UC medical center there and several other nearby organizations in the La Jolla area, including the Salk Institute for Biological Studies, the Scripps Research Institute and the Sanford-Burnham Medical Research Institute.
SCIENCE
January 11, 2008 | Karen Kaplan, Los Angeles Times Staff Writer
Scientists reported Thursday that for the first time they have made human embryonic stem cells without destroying embryos, a development that the government's top stem cell official said would make the controversial research eligible for federal funding. Story Landis, who chairs the National Institute of Health's stem cell task force, said that with certain safeguards, the new method appeared to comply with federal restrictions that have largely cut scientists off from the $28 billion the government spends on medical research each year.
SCIENCE
April 1, 2014 | By Monte Morin
Research that made international headlines with a purported breakthrough in the creation of highly valuable stem cells has been found to contain falsified and manipulated data, according to a panel of Japanese investigators. At a news conference in Tokyo on Tuesday, the government's RIKEN research institute announced that it had concluded an investigation into allegations of misconduct, and found that the lead author of the study had improperly altered images of DNA fragments used in the research.
SCIENCE
September 11, 2013 | By Eryn Brown
Researchers have reprogrammed cells inside living mice -- and have discovered that the pluripotent stem cells created in the process are even more flexible than those derived from embryos or grown in laboratory dishes. Someday the achievement might help scientists devise ways to treat human disease by directly regenerating tissues within human patients, said Manuel Serrano, an investigator at the Spanish National Cancer Research Center in Madrid and senior author of a study ( abstract here )
BUSINESS
August 5, 2013 | By Ricardo Lopez
For a $330,000 burger, taste testers thought the flavor fell a little flat.  The hefty price tag, however, wasn't for some fancy, rare cut of meat. In fact, this meat had never so much as mooed in a previous life: It was beef grown in a laboratory.  Dutch scientists Monday unveiled their ambitious research project, years in the making, with a public taste test of their cultured beef in London.  Volunteer tasters sampled hamburger made from the lab-grown beef made from stem cells.
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