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May 27, 1998 | From Times Staff and Wire Reports
A new product made of human skin cells won FDA approval for use in treating certain kinds of wounds. The product, called Apligraf, is made of live cells from the foreskin of a newborn's penis mixed with collagen cells from a cow. It is made by Canton, Mass.-based Organogenesis. The Food and Drug Administration said it had approved the product for use in treating venous skin ulcers, which are hard to heal because of a lack of blood flow to the skin.
June 8, 2012 | By Thomas H. Maugh II
Bacteria in the gut play a crucial role in human health, and imbalances in bacterial populations can contribute to many disorders. New research suggests that fungi, though not as common in the intestines as bacteria, may also play a role in causing and modulating disease. The results could lead to new treatments for conditions such as inflammatory bowel disease, ulcerative colitis and Crohn's disease. An estimated 1.4 million Americans have some form of inflammatory bowel disease, which can cause inflammation, ulcers in the bowel, abdominal pain, diarrhea, bleeding, fatigue, weight loss and loss of appetite.
May 31, 2003 | From Times Staff and Wire Reports
Researchers have discovered how the bacterium Helicobacter pylori causes ulcers, and it is not what they expected. A team from Stanford University and the IRIS research institute in Siena, Italy, reported in Friday's issue of Science that the bacterium binds to the junctions between cells in the intestinal lining, injecting a protein that loosens the binding between cells. That causes leakiness of the lining, allowing stomach acids to irritate underlying tissue and produce ulcers.
August 24, 2011 | By Jeannine Stein, Los Angeles Times / For the Booster Shots blog
Casey Abrams wowed audiences on Season 10 of "American Idol" with his unique bluesy singing style. But his talent was briefly overshadowed when he was hospitalized during the show for complications of ulcerative colitis, a condition he was diagnosed with in college, but hadn't publicly revealed. Looking back now, Abrams says the episode was a blessing in disguise. "When I read on TMZ that I was in the hospital I thought, I guess I have to talk about it now. It was a good kick in the butt to get it out there.
March 15, 1999
Even laypeople have learned in the past several years that a major cause of ulcers is infection by Helicobacter pylori, and that an effective treatment for such ulcers is antibiotics. Why hasn't Health columnist Kristl Buluran ("Don't Let Ulcers Get So Bad You Need Surgery," Feb. 15) kept up? --IRWIN B. MARGILOFF Via e-mail In the article by Kristl Buluran on Feb. 15, I was surprised that there was only one mention (the last sentence) of the involvement of the bacterium Helicobacter pylori.
May 16, 1994 | LESLIE BERKMAN
In recognition that many stomach ulcers are caused by bacteria, rather than stress or diet, a UC Irvine physician is launching a new study to evaluate the effectiveness of a combination of bacteria-destroying medications in treating ulcer patients. Dr. Hooshang Meshkinpour, a UCI gastroenterologist, said the aim of the research project is to find the most effective method for healing ulcers and eradicating the bacteria, called H.
June 25, 1987 | HARRY NELSON, Times Medical Writer
A USC researcher has found a promising non-surgical way to treat life-threatening bleeding ulcers by coagulating the blood with electrical current. In a report in this week's New England Journal of Medicine, Dr. Loren Laine said patients treated with this technique, called multipolar electrocoagulation, required less than half as much blood and had to spend fewer days in the hospital.
January 21, 1999 | From Associated Press
Russian President Boris N. Yeltsin's ulcer will not require surgery because drug treatment appears to be working, his doctors decided Wednesday. Yeltsin, who has been hospitalized five times since his 1996 reelection, underwent a gastroscopy Wednesday, in which a fiber-optic thread with a tiny camera was passed through his mouth into his stomach, allowing doctors to inspect the ulcer.
July 13, 1996
Beckman Instruments Inc. said Friday that its blood diagnostic test for the bacteria that causes most cases of peptic ulcers was approved by federal regulators. The U.S. Food and Drug Administration approved Beckman's FlexSure Hp, a whole blood test to detect evidence of H.pylori, the bacteria responsible for up to 90% of peptic ulcers, the company said. The test uses a three-step, four-minute procedure that can be performed in a physician's office.
May 1, 1989 | From Times staff and wire reports
Regular doses of a common ulcer medicine, taken even when people are healthy, can keep ulcers from returning, a study has found. The ulcer drugs ranitidine and cimetidine can heal digestive ulcers within a month or two, but doctors usually prescribe them only during flare-ups, not between them. The ulcers usually return. In the latest study, conducted on people with duodenal ulcers, doctors showed that regular maintenance therapy with ranitidine cut the chances of ulcers returning almost in half.
December 1, 2010 | By Thomas H. Maugh II, Los Angeles Times
A 34-year-old Northern California man with ulcerative colitis who decided to treat himself by swallowing parasitic worms has provided new information about how the worms might help to soothe and heal a variety of intestinal inflammations, researchers reported Wednesday. A growing body of evidence suggests that several different types of parasitic worms might be useful in treating such disorders, but there has been little evidence about how the worms might bring about positive changes. By allowing doctors to monitor changes in his immune system following ingestion of the worms, the man has provided the first clues about that mechanism.
March 28, 2009 | Lisa Dillman
Strange days and nights, indeed. Odd things seem to happen to the Clippers before, during and after games against the San Antonio Spurs. Of course, there is no containing this general Clippers strangeness. But it has appeared to occur with frequency when the Spurs are in proximity. Less than a month ago, it was Clippers owner Donald Sterling storming into the locker room to verbally thrash his players after a lopsided loss to the Spurs at Staples Center.
September 4, 2008 | Rene Lynch, Times Staff Writer
Celebrity chef Gordon Ramsay says he's getting an ulcer. It's not from the stress of running restaurants from West Hollywood to Dubai. Nor is it the launch of his newest cookbook. This ulcer is courtesy of "Kitchen Nightmares." The Fox reality show -- which returns tonight for a two-hour special at 8 p.m. -- drops Ramsay into U.S. restaurants on the brink of bankruptcy in a last-ditch effort to turn them around. The normally hard-charging Ramsay says it's one thing to put himself on the line or bark at contestants who willingly sign up for the abuse they've got coming on Ramsay's other Fox reality show, "Hell's Kitchen."
July 12, 2008 | From Times Staff and Wire Reports
Taking an antidepressant may increase the odds of developing an ulcer, although the overall risk remains small, according to a report published Tuesday in the Archives of General Psychiatry. The study of 1,321 people with gastrointestinal bleeding found that such drugs as Eli Lilly's Prozac, Forest Laboratories' Celexa and Lexapro, GlaxoSmithKline's Paxil, Pfizer's Zoloft, and Wyeth's Effexor could trigger gastrointestinal bleeding in one of every 2,000 patients. The risk increased to 1 in 250 patients when aspirin or pain drugs also were taken, according to the report.
June 1, 2007
Re "You know what makes me sick?" Opinion, May 27 As a practicing gastroenterologist and a board member of the Celiac Disease Foundation, I find it unfortunate that Heather Abel accuses physicians of pushing pills after being bought off by drug companies. The failure to diagnose celiac disease is because of symptoms (if any) that are typically subtle and nonspecific, not because of a conspiracy between physicians and drug companies. Abel says her irritable bowel syndrome was treated with Celebrex, which caused ulcers.
October 4, 2005 | Thomas H. Maugh II, Times Staff Writer
Two Australian researchers who discovered that stomach ulcers are caused by a bacterium, not by emotional stress or spicy foods, were awarded the 2005 Nobel Prize in Physiology or Medicine on Monday. Dr. J. Robin Warren, 68, and Dr. Barry J. Marshall, 54, overturned the belief held by physicians for decades by isolating a spiral-shaped bacterium called Helicobacter pylori from humans and ultimately demonstrating that it could produce serious lesions in the stomach.
December 28, 1988
The Food and Drug Administration announced approval of a new prescription drug it said can prevent stomach ulcers that afflict some of the millions of people who take medicine for arthritis. To be marketed under the trade name Cytotec by G. D. Searle of Skokie, Ill., the drug--misoprostol--is to be labeled for use in patients at high risk for developing complications of stomach ulcers while on arthritis drugs. That would include the elderly and patients of any age with another serious illness.
August 30, 1988 | ALLAN PARACHINI, Times Staff Writer
Ulcer sufferers, and people with more garden variety heartburn and indigestion, may be able to look forward to two new and interrelated treatments. But both treatments--a possible new drug for ulcer sufferers and the proposed recasting of an established remedy as an over-the-counter antacid--have raised questions about effectiveness and acceptable balance between risk and benefit.
October 19, 2004 | From Reuters
The AFL-CIO and two California consumer groups Monday sued AstraZeneca, accusing the company of misleading patients into switching to its expensive new ulcer drug just as the patent on its nearly identical but older Prilosec pill was set to expire. The suit was filed in Los Angeles County Superior Court by the labor union, the Congress of California Seniors and the California Alliance for Retired Americans on behalf of consumers nationwide who purchased the newer pill, called Nexium.
June 28, 2004 | Jane E. Allen, Times Staff Writer
About half of older patients regularly taking Vioxx or Celebrex for pain also appear to be on aspirin therapy to prevent heart attacks. But that combination could be endangering their health. Combining the two drugs increases the risk of ulcers and gastrointestinal bleeding. Even worse, about half the aspirin-takers are further boosting their bleeding risk by using excessive doses of aspirin, a new survey indicates.
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