August 19, 2012 |
Because 200 mph is useless if you can't get some bugs in your hair, McLaren introduced to the world a convertible version of its already excellent MP4-12C supercar this weekend at Pebble Beach. Dubbed the 12C Spider, the car has a retractable hardtop that folds away in a scant 17 seconds and at speeds up to 19 mph. The car'Ã?Â?s power remains the same, with 616 horsepower coming from a 3.8-liter twin-turbocharged V-8 engine, routing power to the rear wheels via a seven-speed, dual-clutch gearbox.
July 11, 2012 |
Researchers have found the first gene mutation that protects against Alzheimer's disease, a finding that supports a now-controversial theory about the cause of the disease and that could eventually lead to the development of new drugs to treat the disorder. The gene mutation also protects against normal dementia of aging, suggesting that the two diseases have mechanisms in common. Alzheimer's affects an estimated 5.4 million Americans, and the prevalence increases with age: 13% of those older than 65 and 45% of those over the age of 85 have it. The disease is characterized by the buildup in the brain of particles called amyloid plaque, which are composed of a protein called amyloid beta.
October 23, 2011 |
1Q84 A Novel Haruki Murakami, translated from the Japanese by Jay Rubin and Philip Gabriel Alfred A. Knopf: 926 pp., $30.50 Here's an unorthodox suggestion: Try to read Haruki Murakami's "1Q84" in as close to a single sitting as you can. It won't be easy - the novel clocks in at 926 pages and is often densely allusive, if readable throughout. Still, there's something about the book that requires the deep immersion, the otherworldly sense of connection/disconnection, that only an extended plunge allows.
September 26, 2011 |
A large number of the world's 300 million people with asthma -- as many as 40% -- don't respond to the inhalers their doctors prescribe to improve lung function. But doctors don't know how to predict which patients will benefit from glucocorticoid therapy (steroid inhalers) and which ones won't. But researchers at the Harvard Medical School have now located a genetic variation that may some day help physicians figure it out. The team's results, published Monday in the New England Journal of Medicine, used a genome-wide analysis of 118 trios (consisting of a child and his or her parents)
July 22, 2011 |
Citing "technical errors" and "inadequate quality control," scientists from Boston University have retracted a study that claimed to have found 150 genetic variants linked to extreme old age. About a year ago, the team, led by geneticist Paola Sebastiani and longevity researcher Dr. Thomas Perls, published results of an examination of the DNA of more than 1,000 centenarians -- people who had lived 100 years or longer. They reported discovering 150...
October 28, 2010 |
Researchers have found more than 15 million places in the human genome where the genetic code differs from person to person, providing a catalog of hot spots for genetic change that should speed the search for genetic causes of such complex disorders as diabetes, Alzheimer's and heart disease. Only 10 years after scientists laboriously unraveled the first sequence of a human genome, an international team said Wednesday that they had sequenced the bulk of the genomes from more than 800 people in the pilot stage of the so-called 1000 Genomes Project, which aims to complete 2,500 sequences by the end of 2012 at a cost of $120 million.