July 10, 2002 |
Three years ahead of schedule, scientists have unexpectedly halted a critical clinical trial testing the effects of hormone replacement therapy on women after menopause because of a slight but significant increase in the risk of breast cancer, heart attacks, blood clots and strokes. The trial, which tracked 16,608 women taking either the hormones estrogen and progestin or a placebo for five years, was brought to an end after a review in late May made it clear that the risks of the hormone regimen outweighed the benefits.
November 4, 2011 |
A significant rise in hip fractures among women is one result of the decade-long slide in the popularity of hormone replacement therapy, researchers report in a new study. The landmark Women's Health Initiative study showed unequivocally that hormone therapy helps strengthen women's bones and prevents fractures of hip, wrist and spine by 27% to 35%. However, hormone use fell out of favor after studies in 2002 showed it raised the risk of breast cancer and did not lower heart-disease risk and, in fact, may elevate the risk in some women.
April 5, 2011 |
Although many women have sworn off hormone therapy, a new analysis from the clinical trial that first unearthed the hormones' risks shows taking estrogen alone for menopausal symptoms, even for several years, may be safer than first thought. The new finding — the latest from the Women's Health Initiative, a federally funded trial that tracked thousands of women taking hormones or placebo pills for years — looked at women who have had hysterectomies and thus can take estrogen unaccompanied by another hormone, progestin.
August 5, 2010
Far fewer women take hormone replacement therapy than did a decade ago, but the drugs are a mixed bag of risks and benefits, as studies occasionally point out. For women who are especially concerned about colon cancer, hormone therapy might be a good idea. A study has found that using hormone replacement therapy for any length of time cut the risk of distal colon cancer in half. The distal part of the colon is closest to the rectum. The longer women took hormone therapy, the greater the reduced risk.
December 9, 2010 |
Estrogen-only hormone replacement therapy may benefit younger postmenopausal women who do not have a uterus, a Canadian researcher said Thursday at the annual meeting of the San Antonio Breast Cancer Symposium. Dr. Joseph Ragaz, an oncologist at the University of British Columbia, presented a re-analysis of the Women's Health Initiative -- which originally concluded that both long-term estrogen-only and estrogen-plus-progestin hormone replacement were too risky for most women.
September 20, 2009 |
Hormone replacement therapy, already linked to increased risk of breast cancer, heart disease and stroke, nearly doubles a woman's risk of dying from lung cancer, researchers reported Saturday in a finding that may be the final blow for a therapy that is already in rapidly declining use. The findings "seriously question whether hormone-replacement therapy has any role in medicine today," Dr. Apar Kishor Ganti of the University of Nebraska Medical...
January 10, 2012 |
Older women who take statin medications to ward off heart attacks are more likely to develop Type 2 diabetes than those who do not take the widely used cholesterol-lowering drugs, a study has found. The report, published Monday in the Archives of Internal Medicine, showed that, in a large group of post-menopausal women, those who took a statin of any type were, on average, 48% likelier to develop Type 2 diabetes than those who didn't. The heightened risk for diabetes was most pronounced in statin-taking women of Asian origin or those with a body mass index, or BMI, in the healthy range.
November 18, 2010 |
Hormone therapy appears to affect the brain differently depending on the age of the woman when she receives it, researchers reported Thursday. Hormone-replacement therapy for women has been the subject of considerable debate. Studies have shown both pros and cons. But hormone use has declined in the last decade because a major study on the issue, the Women's Health Initiative , found that the risks of taking hormones appeared to outweigh significantly the benefits in older postmenopausal women.
May 29, 2012 |
Women who are past menopause and healthy should not use hormone replacement therapy in hopes of warding off dementia, bone fractures or heart disease, says a new analysis by the government task force that weighs the risks and benefits of screening and other therapies aimed at preventing illness. The recommendation by the U.S. Preventive Services Task Force does not necessarily apply to women who use hormone replacement therapy to reduce menopausal symptoms such as hot flashes, night sweats and vaginal dryness.
July 18, 2013 |
Hormone replacement therapy has plummeted among U.S. women since the Women's Health Initiative cut short its Estrogen Plus Progestin Trial in 2002, when study results revealed that women who took the two-hormone therapy suffered adverse effects and higher mortality. But the widespread rejection since of all hormone replacement therapies among menopausal women has been misguided, a team of researchers from the Yale School of Medicine in New Haven, Conn., wrote Thursday in the online edition of the American Journal of Public Health . Looking at a separate group of women than those followed in the 2002 trial - women ages 50 to 59 who had had hysterectomies - Dr. Philip Sarrel and colleagues calculated that rejecting estrogen-only hormone therapy resulted in the early deaths of nearly 50,000 women between 2002 and 2011.