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Women S Health Initiative

SCIENCE
July 10, 2002 | ROSIE MESTEL, TIMES STAFF WRITER
Three years ahead of schedule, scientists have unexpectedly halted a critical clinical trial testing the effects of hormone replacement therapy on women after menopause because of a slight but significant increase in the risk of breast cancer, heart attacks, blood clots and strokes. The trial, which tracked 16,608 women taking either the hormones estrogen and progestin or a placebo for five years, was brought to an end after a review in late May made it clear that the risks of the hormone regimen outweighed the benefits.
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NEWS
November 4, 2011 | By Shari Roan, Los Angeles Times / For the Booster Shots blog
A significant rise in hip fractures among women is one result of the decade-long slide in the popularity of hormone replacement therapy, researchers report in a new study. The landmark Women's Health Initiative study showed unequivocally that hormone therapy helps strengthen women's bones and prevents fractures of hip, wrist and spine by 27% to 35%. However, hormone use fell out of favor after studies in 2002 showed it raised the risk of breast cancer and did not lower heart-disease risk and, in fact, may elevate the risk in some women.
NEWS
October 19, 2010
Estrogen-plus-progestin hormone replacement therapy increases the risk of breast cancer in postmenopausal women. Now a longer-term study of the problem shows the higher risk of breast cancer continues among women who took hormones but stopped, that the cancer in these women may be more advanced and that the likelihood of dying of breast cancer is increased. The link between hormone therapy and breast cancer was confirmed with the conclusion of the Women's Health Initiative study in 2005, based on about 5 1/2 years of data.
SCIENCE
May 29, 2012 | Melissa Healy
Women who are past menopause and healthy should not use hormone replacement therapy in hopes of warding off dementia, bone fractures or heart disease, says a new analysis by the government task force that weighs the risks and benefits of screening and other therapies aimed at preventing illness. The recommendation by the U.S. Preventive Services Task Force does not necessarily apply to women who use hormone replacement therapy to reduce menopausal symptoms such as hot flashes, night sweats and vaginal dryness.
NEWS
November 18, 2010 | By Shari Roan, Los Angeles Times
Hormone therapy appears to affect the brain differently depending on the age of the woman when she receives it, researchers reported Thursday. Hormone-replacement therapy for women has been the subject of considerable debate. Studies have shown both pros and cons. But hormone use has declined in the last decade because a major study on the issue, the Women's Health Initiative , found that the risks of taking hormones appeared to outweigh significantly the benefits in older postmenopausal women.
NEWS
April 6, 2011 | By Shari Roan, Los Angeles Times
Hormone therapy has been one of the most confusing issues in women's health over the last decade. Now, a study from the Women's Health Initiative shows the increased risk of stroke found among women who take estrogen-only hormone therapy disappears after they stop the pills but the reduced risk of breast cancer -- believed by some to result from hormone use after natural menopause -- is maintained. The findings should help women who have had a hysterectomy better weigh their risks and benefits of taking estrogen based on their age and symptoms.
HEALTH
January 10, 2012 | By Melissa Healy, Los Angeles Times
Older women who take statin medications to ward off heart attacks are more likely to develop Type 2 diabetes than those who do not take the widely used cholesterol-lowering drugs, a study has found. The report, published Monday in the Archives of Internal Medicine, showed that, in a large group of post-menopausal women, those who took a statin of any type were, on average, 48% likelier to develop Type 2 diabetes than those who didn't. The heightened risk for diabetes was most pronounced in statin-taking women of Asian origin or those with a body mass index, or BMI, in the healthy range.
CALIFORNIA | LOCAL
August 9, 2011 | Elaine Woo
Dr. Bernadine Healy, a hard-charging cardiologist and educator who was the first woman to lead the National Institutes of Health and later commanded American Red Cross relief efforts after the 9/11 terrorist attacks, died Saturday at her home in Gates Mills, Ohio. She was 67. The cause was brain cancer, said her daughter, Bartlett Ann Bulkley. Healy, a Republican who served in the Reagan and George H.W. Bush administrations, was known as a no-nonsense leader who ruffled politicians and dealt swiftly with incompetence, traits that frequently drew controversy during a career devoted to humanitarian goals.
SCIENCE
September 20, 2009 | Thomas H. Maugh II
Hormone replacement therapy, already linked to increased risk of breast cancer, heart disease and stroke, nearly doubles a woman's risk of dying from lung cancer, researchers reported Saturday in a finding that may be the final blow for a therapy that is already in rapidly declining use. The findings "seriously question whether hormone-replacement therapy has any role in medicine today," Dr. Apar Kishor Ganti of the University of Nebraska Medical...
SCIENCE
July 18, 2013 | By Eryn Brown, This post has been updated. See below for details.
Hormone replacement therapy has plummeted among U.S. women since the Women's Health Initiative cut short its Estrogen Plus Progestin Trial in 2002, when study results revealed that women who took the two-hormone therapy suffered adverse effects and higher mortality. But the widespread rejection since of all hormone replacement therapies among menopausal women has been misguided, a team of researchers from the Yale School of Medicine in New Haven, Conn., wrote Thursday in the online edition of the American Journal of Public Health .  Looking at a separate group of women than those followed in the 2002 trial - women ages 50 to 59 who had had hysterectomies - Dr. Philip Sarrel and colleagues calculated that rejecting estrogen-only hormone therapy resulted in the early deaths of nearly 50,000 women between 2002 and 2011.
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